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A9NA93 (HEM6_COXBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:COXBURSA331_A1921
OrganismCoxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP]
Taxonomic identifier360115 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_1000079256

Regions

Region53 – 6210Important for dimerization By similarity
Region113 – 1153Substrate binding By similarity
Region245 – 28036Important for dimerization By similarity
Region263 – 2686Substrate binding By similarity

Sites

Active site1111Proton donor By similarity
Binding site971Substrate By similarity
Site1801Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
A9NA93 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: CC956D6B15BD13D7

FASTA31036,394
        10         20         30         40         50         60 
MRKDRQNKIT EVGIYLKGLQ NRLCRAFEKE EGESRFQETL WEKPNGGGGR TRLLTEGHVI 

        70         80         90        100        110        120 
EQGGVNFSCV YGNQLPPAAT QKHPEISGFA FQAEGLSLVI HPRNPYVPTV HANFRFFIAG 

       130        140        150        160        170        180 
KDEADPRWWF GGGYDLTPYY GFEEDCRHWH RVAKKACDRF GEAIYPRFKA ACDDYFYLKH 

       190        200        210        220        230        240 
RNEPRGIGGL FFDDLNEWEF KRCFEFIKIL GDSFLEAYLP IMQNRKNHPY GERQREFQLY 

       250        260        270        280        290        300 
RRGRYVEFNL LYDRGTRFGL EFGGRTESIL MSLPPRVVWR PNWEPEPGSE EARLYEDYLV 

       310 
RRNWVSVSGA

« Hide

References

[1]"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
Seshadri R., Samuel J.E.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 331 / Henzerling II.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000890 Genomic DNA. Translation: ABX77533.1.
RefSeqYP_001597552.1. NC_010117.1.

3D structure databases

ProteinModelPortalA9NA93.
SMRA9NA93. Positions 8-305.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9NA93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5793396.
GenomeReviewsGene locus hemF in contig CP000890_GR.
KEGGcbs:COXBURSA331_A1921.
PATRIC17928086. VBICoxBur33747_1902.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Enzyme and pathway databases

BioCycCBUR360115:COXBURSA331_A1921-MONOMER.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_COXBR
AccessionPrimary (citable) accession number: A9NA93
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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