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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-1908-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:COXBURSA331_A1903
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Glycine cleavage system H proteinPRO_1000078729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651N6-lipoyllysineUniRule annotation

Proteomic databases

PRIDEiA9NA78.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9NA78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10683Lipoyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

HOGENOMiHOG000239392.
KOiK02437.
OMAiNTDPYGE.
OrthoDBiEOG60CWTC.

Family and domain databases

HAMAPiMF_00272. GcvH.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR000089. Biotin_lipoyl.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiPF01597. GCV_H. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NA78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPAELYY SKNHEWMRKE SDETFTVGIT DHAQEQLGDL VFVELPETNI
60 70 80 90 100
HVDAGDEVAV VESVKTAADV YSPLSGKVIE INNALENEPA TVNRDPYGDG
110 120 130
WLYRITIDDE KELNDLLDAD GYQTLIEAES
Length:130
Mass (Da):14,594
Last modified:February 5, 2008 - v1
Checksum:i64790572C23AACFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000890 Genomic DNA. Translation: ABX78372.1.
RefSeqiWP_005770508.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX78372; ABX78372; COXBURSA331_A1903.
KEGGicbs:COXBURSA331_A1903.
PATRICi17928048. VBICoxBur33747_1883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000890 Genomic DNA. Translation: ABX78372.1.
RefSeqiWP_005770508.1. NC_010117.1.

3D structure databases

ProteinModelPortaliA9NA78.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA9NA78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX78372; ABX78372; COXBURSA331_A1903.
KEGGicbs:COXBURSA331_A1903.
PATRICi17928048. VBICoxBur33747_1883.

Phylogenomic databases

HOGENOMiHOG000239392.
KOiK02437.
OMAiNTDPYGE.
OrthoDBiEOG60CWTC.

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-1908-MONOMER.

Family and domain databases

HAMAPiMF_00272. GcvH.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR000089. Biotin_lipoyl.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiPF01597. GCV_H. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiGCSH_COXBR
AccessioniPrimary (citable) accession number: A9NA78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.