Dihydroorotase - Coxiella burnetii (strain RSA 331 / Henzerling II)

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Reviewed, UniProtKB/Swiss-Prot A9NA67 (PYRC_COXBR)

Last modified November 3, 2009. Version 19. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3

Gene names

Name:	pyrC
Ordered Locus Names:	COXBURSA331_A1891

Organism

Coxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H₂O = N-carbamoyl-L-aspartate. HAMAP MF_00219
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

348

Dihydroorotase HAMAP MF_00219

PRO_1000100038

Sites

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1; via carbamate group By similarity

Metal binding

1

Zinc 2; via carbamate group By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 1 By similarity

Amino acid modifications

Modified residue

1

N6-carboxylysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A9NA67-1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 200D102EF18BDEA3
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348

38,675

        10         20         30         40         50         60 
MKKITLIRPD DWHCHLRDGS YLPRTVADIA AQFNRAIVMP NLVPPITTVQ QAKAYYDRIK 

        70         80         90        100        110        120 
AHVPKSSNFE PLMTLYLTES TPQQEIKAAQ QSGIIVACKL YPAGATTHSQ AGVKDLKAIY 

       130        140        150        160        170        180 
TLLETMQSVD LPLLIHGEVV DYAVDIFDRE AVFIERELLP LVETFPQLRI VFEHISTKIA 

       190        200        210        220        230        240 
VDFVLEAPSK LGATITPHHL LFNRNDLLSG SIRPHYYCLP ILKTSEDQMA LIQAATSGNP 

       250        260        270        280        290        300 
KFFLGTDSAP HSQTKKQSIC GSAGIYNAPA AIALYAEIFA SQNALDKLEG FASRFGAEFY 

       310        320        330        340 
GLPLNNSQIT LIHQPWQVAE SLPFGNELVV PLFAGQTLQW QIKSHEHK

References

[1]	"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates." Seshadri R., Samuel J.E. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CP000890 Genomic DNA. Translation: ABX77271.1.
RefSeq	YP_001597526.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5792777.
GenomeReviews	Gene locus pyrC in contig CP000890_GR.
KEGG	cbs:COXBURSA331_A1891.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IMPNLVP.
Family and domain databases
HAMAP	MF_00219. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
PIRSF	PIRSF001237. DHOdimr. 1 hit.
TIGRFAMs	TIGR00856. pyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. False negative. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRC_COXBR

Accession

Primary (citable) accession number: A9NA67

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents