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A9N9G2 (SYR_COXBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:COXBURSA331_A0077
OrganismCoxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP]
Taxonomic identifier360115 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000076211

Regions

Motif128 – 13811"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A9N9G2 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: EF8C877F2E9D97DB

FASTA58666,076
        10         20         30         40         50         60 
MKQQIETLLN QAIERLKTKG VLKPEVTPVI KITHTTDPQH GDFATNLALT LSKAAGMSPH 

        70         80         90        100        110        120 
ALAEKIVEAL PPSGQITEVE IAGPGFINFF VTEGSYQTVV SSILKAGKDY GRSEMGKGQR 

       130        140        150        160        170        180 
VHMEYVSANP TGPLHVGHGR GAAYGACVAN LLNAAGFEVH REYYVNDAGR QMGILALSVW 

       190        200        210        220        230        240 
VRYLQGYEAS IELPKNAYQG EYIIDIAEAL KAKYGKQFYH SVESIQAKIP EEIDSNADPE 

       250        260        270        280        290        300 
AYLDAWVTAQ KDLLGPKDFE CVFQAALDSI LNDIKNDLEE FGVTYDDWFP ESRLVREGLI 

       310        320        330        340        350        360 
QEGLDLLTKH GYVYEKNGAQ WFRATALGDE KDRVLIRKNG LPTYFAADVA YHLHKFNQGY 

       370        380        390        400        410        420 
DQIIDIFGAD HHGYIPRIRG FLKGLGKAPE KLHILLVQFA ILYRGNEKVS MSTRGGTFVT 

       430        440        450        460        470        480 
LRELRHEVGN DAARFFYIMR KPDQHLDFDL ELAKSQSNEN PVYYIQYAHA RICSVFRQLK 

       490        500        510        520        530        540 
TTQKNWDRPR GMENLSLLST NYEKELLATL GRYPEVIKRA AMNYAPHLLA HYLQTLANQF 

       550        560        570        580 
HTYYNAERFL IEDDNLRNAR LNLINAVQQI IRNGLTLLGV SAPEEM 

« Hide

References

[1]"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
Seshadri R., Samuel J.E.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 331 / Henzerling II.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000890 Genomic DNA. Translation: ABX78394.1.
RefSeqYP_001595968.1. NC_010117.1.

3D structure databases

ProteinModelPortalA9N9G2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360115.COXBURSA331_A0077.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX78394; ABX78394; COXBURSA331_A0077.
GeneID5794048.
KEGGcbs:COXBURSA331_A0077.
PATRIC17924431. VBICoxBur33747_0125.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAMEHMGFG.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycCBUR360115:GI0X-76-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_COXBR
AccessionPrimary (citable) accession number: A9N9G2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries