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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-76-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:COXBURSA331_A0077
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008557 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Arginine--tRNA ligasePRO_1000076211Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A0077.

Structurei

3D structure databases

ProteinModelPortaliA9N9G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 13811"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiVGFGTMM.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9N9G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQIETLLN QAIERLKTKG VLKPEVTPVI KITHTTDPQH GDFATNLALT
60 70 80 90 100
LSKAAGMSPH ALAEKIVEAL PPSGQITEVE IAGPGFINFF VTEGSYQTVV
110 120 130 140 150
SSILKAGKDY GRSEMGKGQR VHMEYVSANP TGPLHVGHGR GAAYGACVAN
160 170 180 190 200
LLNAAGFEVH REYYVNDAGR QMGILALSVW VRYLQGYEAS IELPKNAYQG
210 220 230 240 250
EYIIDIAEAL KAKYGKQFYH SVESIQAKIP EEIDSNADPE AYLDAWVTAQ
260 270 280 290 300
KDLLGPKDFE CVFQAALDSI LNDIKNDLEE FGVTYDDWFP ESRLVREGLI
310 320 330 340 350
QEGLDLLTKH GYVYEKNGAQ WFRATALGDE KDRVLIRKNG LPTYFAADVA
360 370 380 390 400
YHLHKFNQGY DQIIDIFGAD HHGYIPRIRG FLKGLGKAPE KLHILLVQFA
410 420 430 440 450
ILYRGNEKVS MSTRGGTFVT LRELRHEVGN DAARFFYIMR KPDQHLDFDL
460 470 480 490 500
ELAKSQSNEN PVYYIQYAHA RICSVFRQLK TTQKNWDRPR GMENLSLLST
510 520 530 540 550
NYEKELLATL GRYPEVIKRA AMNYAPHLLA HYLQTLANQF HTYYNAERFL
560 570 580
IEDDNLRNAR LNLINAVQQI IRNGLTLLGV SAPEEM
Length:586
Mass (Da):66,076
Last modified:February 5, 2008 - v1
Checksum:iEF8C877F2E9D97DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000890 Genomic DNA. Translation: ABX78394.1.
RefSeqiYP_001595968.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX78394; ABX78394; COXBURSA331_A0077.
GeneIDi5794048.
KEGGicbs:COXBURSA331_A0077.
PATRICi17924431. VBICoxBur33747_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000890 Genomic DNA. Translation: ABX78394.1.
RefSeqiYP_001595968.1. NC_010117.1.

3D structure databases

ProteinModelPortaliA9N9G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A0077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX78394; ABX78394; COXBURSA331_A0077.
GeneIDi5794048.
KEGGicbs:COXBURSA331_A0077.
PATRICi17924431. VBICoxBur33747_0125.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiVGFGTMM.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-76-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiSYR_COXBR
AccessioniPrimary (citable) accession number: A9N9G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 1, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.