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A9N915

- A9N915_COXBR

UniProt

A9N915 - A9N915_COXBR

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Protein

Thymidine kinase

Gene
tdk, COXBURSA331_A0016
Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi88 – 914ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-16-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:COXBURSA331_A0016Imported
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)Imported
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A0016.

Structurei

3D structure databases

ProteinModelPortaliA9N915.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9N915-1 [UniParc]FASTAAdd to Basket

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MAKLHFYYSA MNAGKSTTLL QSSYNYNERG MDTLVFLPVV DDREGERKIA    50
TRIGLSGKTI ALTKDTNLFK CISDKLAENP NIRCVLVDEA QFLTKSQVEA 100
LALVTDELNL PVLAYGIRTD FQGEPFEGSV YLLAWADLLI EIKTICHCGR 150
KATMNLRIDD EGNPIREGEQ IRLGGNDRYT ATCRKHFRLG QPTQTK 196
Length:196
Mass (Da):22,038
Last modified:February 5, 2008 - v1
Checksum:i0B41004F74A42C05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX79047.1.
RefSeqiWP_010958632.1. NC_010117.1.
YP_001595916.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX79047; ABX79047; COXBURSA331_A0016.
GeneIDi5794807.
KEGGicbs:COXBURSA331_A0016.
PATRICi17924305. VBICoxBur33747_0062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX79047.1 .
RefSeqi WP_010958632.1. NC_010117.1.
YP_001595916.1. NC_010117.1.

3D structure databases

ProteinModelPortali A9N915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360115.COXBURSA331_A0016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX79047 ; ABX79047 ; COXBURSA331_A0016 .
GeneIDi 5794807.
KEGGi cbs:COXBURSA331_A0016.
PATRICi 17924305. VBICoxBur33747_0062.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci CBUR360115:GI0X-16-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiA9N915_COXBR
AccessioniPrimary (citable) accession number: A9N915
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi