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A9N8H8

- NADK_COXBR

UniProt

A9N8H8 - NADK_COXBR

Protein

NAD kinase

Gene

nadK

Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei78 – 781Proton acceptorUniRule annotation
    Binding sitei162 – 1621NADUniRule annotation
    Binding sitei179 – 1791NADUniRule annotation
    Binding sitei181 – 1811NADUniRule annotation
    Binding sitei252 – 2521NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 792NADUniRule annotation
    Nucleotide bindingi151 – 1522NADUniRule annotation
    Nucleotide bindingi192 – 1976NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR360115:GI0X-1450-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:COXBURSA331_A1445
    OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
    Taxonomic identifieri360115 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000008557: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299NAD kinasePRO_1000079487Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360115.COXBURSA331_A1445.

    Structurei

    3D structure databases

    ProteinModelPortaliA9N8H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9N8H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIVSKPSF NRIALMGREG VEGVPETLAA LKDYLVSLNR EVILEENAAH    50
    MIDGSRLLTV PANDLKKKAD LLIVVGGDGS LLNAAHIAVP QQLSVLGINR 100
    GRLGFLTDIP PNELTQISDI LDGHYREEVR FLLEGTVEEG DEIVAQGIAL 150
    NDIVLLPGNA PKMIEFDIFI NDEFVCNQRA DGLIITTPTG STAYALSGGG 200
    PILHPQLNAM ALVPMFPHTL SSRPIVVDAE SQIKITISPE NDVSPYVSND 250
    GQERVSIKPG GNVYTRKYHY PLHLIHPTDY NYYDTLRRKL DWEKRAAKV 299
    Length:299
    Mass (Da):32,882
    Last modified:February 5, 2008 - v1
    Checksum:iD0765CF90203DC51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000890 Genomic DNA. Translation: ABX78373.1.
    RefSeqiWP_012220591.1. NC_010117.1.
    YP_001597148.1. NC_010117.1.

    Genome annotation databases

    EnsemblBacteriaiABX78373; ABX78373; COXBURSA331_A1445.
    GeneIDi5794806.
    KEGGicbs:COXBURSA331_A1445.
    PATRICi17927171. VBICoxBur33747_1452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000890 Genomic DNA. Translation: ABX78373.1 .
    RefSeqi WP_012220591.1. NC_010117.1.
    YP_001597148.1. NC_010117.1.

    3D structure databases

    ProteinModelPortali A9N8H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360115.COXBURSA331_A1445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX78373 ; ABX78373 ; COXBURSA331_A1445 .
    GeneIDi 5794806.
    KEGGi cbs:COXBURSA331_A1445.
    PATRICi 17927171. VBICoxBur33747_1452.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CBUR360115:GI0X-1450-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
      Seshadri R., Samuel J.E.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 331 / Henzerling II.

    Entry informationi

    Entry nameiNADK_COXBR
    AccessioniPrimary (citable) accession number: A9N8H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3