Glucose-1-phosphate thymidylyltransferase - Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

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A9N7P9 (A9N7P9_SALPB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Glucose-1-phosphate thymidylyltransferase RuleBase RU003706
EC=2.7.7.24 RuleBase RU003706

Gene names

Ordered Locus Names:

SPAB_00935

Organism

Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella enterica subsp. enterica serovar Paratyphi B

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis By similarity. RuleBase RU003706
Catalytic activity	dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose. RuleBase RU003706
Sequence similarities	Belongs to the glucose-1-phosphate thymidylyltransferase family. RuleBase RU003706

Ontologies

Keywords
Ligand	Magnesium RuleBase RU003706 Metal-binding RuleBase RU003706
Molecular function	Nucleotidyltransferase RuleBase RU003706 Transferase
Technical term	3D-structure PDB 1MP5 PDB 1MP4 PDB 1MP3 Complete proteome
Gene Ontology (GO)
Biological process	extracellular polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	glucose-1-phosphate thymidylyltransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

A9N7P9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: E2F77E1F62862842
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294

32,666

        10         20         30         40         50         60 
MEMKMRKGII LAGGSGTRLY PVTMAVSKQL LPIYDKPMIY YPLSTLMLAG IRDILIISTP 

        70         80         90        100        110        120 
QDTPRFQQLL GDGSQWGLNL QYKVQPSPDG LAQAFIIGEE FIGNDDCALV LGDNIFYGHD 

       130        140        150        160        170        180 
LPKLMEAAVN KESGATVFAY HVNDPERYGV VEFDQSGTAV SLEEKPLQPK SNYAVTGLYF 

       190        200        210        220        230        240 
YDNSVVEMAK NLKPSARGEL EITDINRIYM DQGRLSVAMM GRGYAWLDTG THQSLIEASN 

       250        260        270        280        290 
FIATIEERQG LKVSCPEEIA FRKNFINAQQ VIELAGPLSK NDYGKYLLKM VKGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Cordes M., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1250 / SPB7.
[2]	"Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering." Barton W.A., Biggins J.B., Jiang J., Thorson J.S., Nikolov D.B. Proc. Natl. Acad. Sci. U.S.A. 99:13397-13402(2002) [PubMed: 12374866] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 3-294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000886 Genomic DNA. Translation: ABX66357.1.

RefSeq

YP_001587190.1. NC_010102.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MP3	X-ray	2.20	A/B	3-294	[»]
1MP4	X-ray	2.20	A/B	3-294	[»]
1MP5	X-ray	2.75	A/B/C/D	3-294	[»]

ProteinModelPortal

SMR

A9N7P9. Positions 3-291.

ModBase

Protein-protein interaction databases

STRING

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

GeneID

GenomeReviews

Gene locus SPAB_00935 in contig CP000886_GR.

KEGG

spq:SPAB_00935.

PATRIC

18529795. VBISalEnt120821_0782.

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

OMA

ProtClustDB

Family and domain databases

InterPro

IPR005907. G1P_thy_trans_s.
IPR005835. NTP_transferase.
[Graphical view]

KO

PANTHER

PTHR22572:SF13. PTHR22572:SF13. 1 hit.

Pfam

PF00483. NTP_transferase. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01207. RmlA. 1 hit.

ProtoNet

Entry information

Entry name

A9N7P9_SALPB

Accession

Primary (citable) accession number: A9N7P9

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info