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Protein

Thiamine kinase

Gene

thiK

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of thiamine to thiamine phosphate.UniRule annotation

Catalytic activityi

ATP + thiamine = ADP + thiamine phosphate.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamine kinase (thiK)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT28901:GH9O-2311-MONOMER.
UniPathwayiUPA00060; UER00596.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine kinaseUniRule annotation (EC:2.7.1.89UniRule annotation)
Gene namesi
Name:thiKUniRule annotation
Ordered Locus Names:SPAB_02314
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Thiamine kinasePRO_1000088028Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9N5J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiamine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219316.
KOiK07251.
OMAiDYLVLMW.
OrthoDBiEOG63NMG9.

Family and domain databases

HAMAPiMF_01604. Thiamine_kinase.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
IPR014093. Thiamine_kinase.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR02721. ycfN_thiK. 1 hit.

Sequencei

Sequence statusi: Complete.

A9N5J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSNNNNPLT RDEILSRYFP QYRPAVAASQ GLSGGSCIIA HDTHRIVLRR
60 70 80 90 100
HHDPDAPPAH FLRHHRALSQ LPASLAPRAL FYTPGWMAVE YLHGVVNSAL
110 120 130 140 150
PDADELAALL YHLHQQPRFG WRIALSPLLA QYWSCCDPAR RTPFWLRRLK
160 170 180 190 200
QLQKNGEPRP LRLAPLHMDV HGDNIVLTSA GLRLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVEDERQH RQLANAYAAC ARIDARQLWR QIRLWHPWVI MLKAGWFEYR
260 270
WRQTGEQQFI RLADETWRQL RMKG
Length:274
Mass (Da):31,844
Last modified:February 5, 2008 - v1
Checksum:i7640165060746CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX67697.1.
RefSeqiWP_001257323.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX67697; ABX67697; SPAB_02314.
KEGGispq:SPAB_02314.
PATRICi18532012. VBISalEnt120821_1877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX67697.1.
RefSeqiWP_001257323.1. NC_010102.1.

3D structure databases

ProteinModelPortaliA9N5J7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX67697; ABX67697; SPAB_02314.
KEGGispq:SPAB_02314.
PATRICi18532012. VBISalEnt120821_1877.

Phylogenomic databases

HOGENOMiHOG000219316.
KOiK07251.
OMAiDYLVLMW.
OrthoDBiEOG63NMG9.

Enzyme and pathway databases

UniPathwayiUPA00060; UER00596.
BioCyciSENT28901:GH9O-2311-MONOMER.

Family and domain databases

HAMAPiMF_01604. Thiamine_kinase.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
IPR014093. Thiamine_kinase.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR02721. ycfN_thiK. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1250 / SPB7.

Entry informationi

Entry nameiTHIK_SALPB
AccessioniPrimary (citable) accession number: A9N5J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: December 9, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.