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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT28901:GH9O-5561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:SPAB_05572
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Inositol 2-dehydrogenasePRO_0000352594Add
BLAST

Proteomic databases

PRIDEiA9N564.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9N564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiKEERMHG.
OrthoDBiEOG6GFGMS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

A9N564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKAGIVGI GMIGSDHLRR LANTVSGVEV VAVCDIVAGR AQAALDKYAI
60 70 80 90 100
EAKDYNDYHD LINDKDVEVV IITASNEAHA DVAVAALNAN KYVFCEKPLA
110 120 130 140 150
VTAADCQRVI EAEQKNGKRM VQIGFMRRYD KGYVQLKNII DSGEIGQPLM
160 170 180 190 200
VHGRHYNAST VPEYKTPQAI YETLIHEIDV MHWLLNEDYK TVKVYFPRQS
210 220 230 240 250
SLVTTLRDPQ LVVMETTSGI NIVVEVFVNC QYGYDIHCDV TGEKGMAELP
260 270 280 290 300
TVASAAVRKA AKYSTDILVD WKQRFIDAYD IEFQDFFDRL NAGLPPAGPT
310 320 330
SWDGYLAAVT ADACVKSQET GNTEIVELPS KPDFYK
Length:336
Mass (Da):37,267
Last modified:February 5, 2008 - v1
Checksum:i5E66D7BC40158197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX70841.1.
RefSeqiWP_000172704.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX70841; ABX70841; SPAB_05572.
KEGGispq:SPAB_05572.
PATRICi18537421. VBISalEnt120821_4506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX70841.1.
RefSeqiWP_000172704.1. NC_010102.1.

3D structure databases

ProteinModelPortaliA9N564.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA9N564.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX70841; ABX70841; SPAB_05572.
KEGGispq:SPAB_05572.
PATRICi18537421. VBISalEnt120821_4506.

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiKEERMHG.
OrthoDBiEOG6GFGMS.

Enzyme and pathway databases

BioCyciSENT28901:GH9O-5561-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1250 / SPB7.

Entry informationi

Entry nameiIOLG_SALPB
AccessioniPrimary (citable) accession number: A9N564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 5, 2008
Last modified: December 9, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.