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Protein

Inosose dehydratase

Gene

iolE

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt, Manganese

Enzyme and pathway databases

BioCyciSENT28901:GH9O-5560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:SPAB_05571
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Inosose dehydratasePRO_0000352378Add
BLAST

Proteomic databases

PRIDEiA9N563.

Structurei

3D structure databases

ProteinModelPortaliA9N563.
SMRiA9N563. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE. 1 hit.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.

Sequencei

Sequence statusi: Complete.

A9N563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNVKKSIKL GIAPIGWRND DIPEIGKENT YKQILSDAAL TGFSGTEVGG
60 70 80 90 100
CYPQDPAELN KELMLRGLEI PGQWFSSFII RDGIASAMNA FEQHCAYLQA
110 120 130 140 150
IHAYVAVVSE QTYSIQGIID KCVYTEKPNF SDSEWQLLCE GLNALGKIAN
160 170 180 190 200
AHGLKLAFHH HMGTGVQTLP EVDRLMENTD PQFVHLLFDT GHIYVSDGDV
210 220 230 240 250
MPLLSKHFDR IKHVHFKDVR NEKLKACRLA KKSFLNSFLD GVFTVPGDGN
260 270 280 290 300
IDFKSVLAYL VGHQYSGWIV VEAEQDPKKY NPLEYAQKGK KHIDELLKNY

L
Length:301
Mass (Da):33,876
Last modified:February 5, 2008 - v1
Checksum:i64B3BE84E3958940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX70840.1.
RefSeqiWP_000282953.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX70840; ABX70840; SPAB_05571.
KEGGispq:SPAB_05571.
PATRICi18537419. VBISalEnt120821_4505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX70840.1.
RefSeqiWP_000282953.1. NC_010102.1.

3D structure databases

ProteinModelPortaliA9N563.
SMRiA9N563. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA9N563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX70840; ABX70840; SPAB_05571.
KEGGispq:SPAB_05571.
PATRICi18537419. VBISalEnt120821_4505.

Phylogenomic databases

HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.

Enzyme and pathway databases

BioCyciSENT28901:GH9O-5560-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE. 1 hit.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIOLE_SALPB
AccessioniPrimary (citable) accession number: A9N563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.