Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9N3N1

- GCSP_SALPB

UniProt

A9N3N1 - GCSP_SALPB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSENT28901:GH9O-3792-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SPAB_03802
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000083212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiA9N3N1.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi272994.SPAB_03802.

Structurei

3D structure databases

ProteinModelPortaliA9N3N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A9N3N1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTLSQLEN RGAFIERHIG PDAAQQQEML NAVGAESLNA LTGQIVPKDI
60 70 80 90 100
QLATPPQVGE AATEYAALAE LKAIAGRNKR FTSYIGMGYT AVQLPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQITLDLTGL DMASASLLDE
160 170 180 190 200
ATAAAEAMAM AKRVSKLKNA NRFFVASDVH PQTLDVVRTR AETFGFDVIV
210 220 230 240 250
DDAAKALDHQ DVFGVLLQQV GTTGEIHDYG ALISELKARK VIVSVAADFM
260 270 280 290 300
ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAK DEFKRSMPGR
310 320 330 340 350
IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV
360 370 380 390 400
YHGPVGLKRI ANRIHRLTDI LAAGLQQKGL KLRHAHYFDT LCVEVADKAA
410 420 430 440 450
VLARAEAAEI NLRSDIHNAV GITLDETTTR ENVAQLFNVL LGDSHGLNIE
460 470 480 490 500
TLDKDVALDS RSIQQSMLRD DAILTHPVFN RYHSETEMMR YMHSLERKDL
510 520 530 540 550
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPPE QAEGYHQMIS
560 570 580 590 600
QLSDWLVKLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI
610 620 630 640 650
PASAHGTNPA SAHMAGMQVV VVACDKNGNI DLDDLRAKAE QHAANLSCIM
660 670 680 690 700
VTYPSTHGVY EETIREVCEV VHQFGGQVYL DGANMNAQVG ITSPGFIGAD
710 720 730 740 750
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIEGMLTRQG
760 770 780 790 800
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQVAILNAN YIASRLKDAY
810 820 830 840 850
PVLYTGRDGR VAHECILDIR PLKEETGISE LDIAKRLIDY GFHAPTMSFP
860 870 880 890 900
VAGTLMVEPT ESEGKAELDR FIDAMLAIRA EIDQVKAGVW PLEDNPLVNA
910 920 930 940 950
PHIQSELVAE WAHPYSREVA VFPAGVADKY WPTVKRLDDV YGDRNLFCSC

VPISDYQ
Length:957
Mass (Da):104,255
Last modified:February 5, 2008 - v1
Checksum:iA8E9AF540A5BD6B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000886 Genomic DNA. Translation: ABX69134.1.
RefSeqiYP_001589967.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX69134; ABX69134; SPAB_03802.
PATRICi18534460. VBISalEnt120821_3070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000886 Genomic DNA. Translation: ABX69134.1 .
RefSeqi YP_001589967.1. NC_010102.1.

3D structure databases

ProteinModelPortali A9N3N1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272994.SPAB_03802.

Proteomic databases

PRIDEi A9N3N1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX69134 ; ABX69134 ; SPAB_03802 .
PATRICi 18534460. VBISalEnt120821_3070.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SENT28901:GH9O-3792-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1250 / SPB7.

Entry informationi

Entry nameiGCSP_SALPB
AccessioniPrimary (citable) accession number: A9N3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3