Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylornithine deacetylase

Gene

argE

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotation, Co2+UniRule annotationNote: Binds 2 Zn2+ or Co2+ ions per subunit.UniRule annotation
  • glutathioneUniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Cobalt or zinc 1UniRule annotation1
Active sitei82UniRule annotation1
Metal bindingi112Cobalt or zinc 1UniRule annotation1
Metal bindingi112Cobalt or zinc 2UniRule annotation1
Active sitei144UniRule annotation1
Metal bindingi145Cobalt or zinc 2UniRule annotation1
Metal bindingi169Cobalt or zinc 1UniRule annotation1
Metal bindingi355Cobalt or zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandCobalt, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
Ordered Locus Names:SPAB_05105
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000848311 – 383Acetylornithine deacetylaseAdd BLAST383

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9N0G7
SMRiA9N0G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000243769
KOiK01438
OMAiCAHQPGE

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9N0G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVLPPFIE IYRALIATPS ISATEESLDQ SNASLITLLA GWFSDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGH GAGGLLLTGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDNKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFSETTAL RPDCAIIGEP TSLQPIRAHK GHISNVVRVL GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHIMQLR DSLKARYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNDLNGLLND ALAPVSERWP GRLTVAELHP
310 320 330 340 350
PIPGYECPPD HQLVEVVEKL LGTKTDVVNY CTEAPFMQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVVHHF CWH
Length:383
Mass (Da):42,202
Last modified:February 5, 2008 - v1
Checksum:iA56BDB11FBDE6475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX70396.1
RefSeqiWP_000800208.1, NC_010102.1

Genome annotation databases

EnsemblBacteriaiABX70396; ABX70396; SPAB_05105
KEGGispq:SPAB_05105
PATRICifig|1016998.12.peg.4791

Similar proteinsi

Entry informationi

Entry nameiARGE_SALPB
AccessioniPrimary (citable) accession number: A9N0G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health