Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylornithine deacetylase

Gene

argE

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotation, Co2+UniRule annotationNote: Binds 2 Zn2+ or Co2+ ions per subunit.UniRule annotation
  • glutathioneUniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Cobalt or zinc 1UniRule annotation
Active sitei82 – 821UniRule annotation
Metal bindingi112 – 1121Cobalt or zinc 1UniRule annotation
Metal bindingi112 – 1121Cobalt or zinc 2UniRule annotation
Active sitei144 – 1441UniRule annotation
Metal bindingi145 – 1451Cobalt or zinc 2UniRule annotation
Metal bindingi169 – 1691Cobalt or zinc 1UniRule annotation
Metal bindingi355 – 3551Cobalt or zinc 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT28901:GH9O-5095-MONOMER.
UniPathwayiUPA00068; UER00110.

Protein family/group databases

MEROPSiM20.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
Ordered Locus Names:SPAB_05105
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Acetylornithine deacetylasePRO_1000084831Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9N0G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000243769.
KOiK01438.
OMAiGTEAPYL.

Family and domain databases

CDDicd03894. M20_ArgE. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE. 1 hit.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9N0G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVLPPFIE IYRALIATPS ISATEESLDQ SNASLITLLA GWFSDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGH GAGGLLLTGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDNKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFSETTAL RPDCAIIGEP TSLQPIRAHK GHISNVVRVL GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHIMQLR DSLKARYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNDLNGLLND ALAPVSERWP GRLTVAELHP
310 320 330 340 350
PIPGYECPPD HQLVEVVEKL LGTKTDVVNY CTEAPFMQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVVHHF CWH
Length:383
Mass (Da):42,202
Last modified:February 5, 2008 - v1
Checksum:iA56BDB11FBDE6475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX70396.1.
RefSeqiWP_000800208.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX70396; ABX70396; SPAB_05105.
KEGGispq:SPAB_05105.
PATRICi18536641. VBISalEnt120821_4134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX70396.1.
RefSeqiWP_000800208.1. NC_010102.1.

3D structure databases

ProteinModelPortaliA9N0G7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM20.974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX70396; ABX70396; SPAB_05105.
KEGGispq:SPAB_05105.
PATRICi18536641. VBISalEnt120821_4134.

Phylogenomic databases

HOGENOMiHOG000243769.
KOiK01438.
OMAiGTEAPYL.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110.
BioCyciSENT28901:GH9O-5095-MONOMER.

Family and domain databases

CDDicd03894. M20_ArgE. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE. 1 hit.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGE_SALPB
AccessioniPrimary (citable) accession number: A9N0G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.