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Protein

CDP-diacylglycerol pyrophosphatase

Gene

cdh

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

CDP-diacylglycerol + H2O = CMP + phosphatidate.UniRule annotation

Pathwayi: CDP-diacylglycerol degradation

This protein is involved in step 1 of the subpathway that synthesizes phosphatidate from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. CDP-diacylglycerol pyrophosphatase (cdh)
This subpathway is part of the pathway CDP-diacylglycerol degradation, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidate from CDP-diacylglycerol, the pathway CDP-diacylglycerol degradation and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciSENT1016998:G1GAK-4326-MONOMER
UniPathwayiUPA00609; UER00664

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol pyrophosphataseUniRule annotation (EC:3.6.1.26UniRule annotation)
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolaseUniRule annotation
CDP-diglyceride hydrolaseUniRule annotation
Gene namesi
Name:cdhUniRule annotation
Ordered Locus Names:SPAB_05037
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000791621 – 251CDP-diacylglycerol pyrophosphataseAdd BLAST251

Structurei

3D structure databases

ProteinModelPortaliA9MZF0
SMRiA9MZF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cdh family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000048713
KOiK01521
OMAiSPFIMLA

Family and domain databases

Gene3Di3.30.428.30, 1 hit
HAMAPiMF_00319 Cdh, 1 hit
InterProiView protein in InterPro
IPR003763 CDP-diacylglyc_Pase
IPR015993 CDP-diacylglyc_Pase_proteobac
IPR038433 CDP-diacylglyc_Pase_sf
IPR036265 HIT-like_sf
PfamiView protein in Pfam
PF02611 CDH, 1 hit
PIRSFiPIRSF001273 CDH, 1 hit
SUPFAMiSSF54197 SSF54197, 1 hit
TIGRFAMsiTIGR00672 cdh, 1 hit

Sequencei

Sequence statusi: Complete.

A9MZF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTGYFLLA VIVIVAATGV GYWKFSGNPD ALREIVLEQC LPDQLQHQNP
60 70 80 90 100
APCAEVKPRA GYVVFKDRHG PLQYLLMPTY RINGTESPLL LEPATPNFFW
110 120 130 140 150
LAWQARGYMS KKYGHDIPDS AVSLAINSRL GRSQDHLHIH ISCIRPDVRE
160 170 180 190 200
QLDNDLTRIS TRWLPLPGGL MGHEYLARRV TESELAQRSP FMMLAEEVPE
210 220 230 240 250
ARDHMGRYAL AVVRQSDDSF VLLATERNLL TLNRASAEEI QDHSCAILSS

R
Length:251
Mass (Da):28,364
Last modified:February 5, 2008 - v1
Checksum:iCF4FABA8E7A2DA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX70328.1
RefSeqiWP_000750767.1, NC_010102.1

Genome annotation databases

EnsemblBacteriaiABX70328; ABX70328; SPAB_05037
KEGGispq:SPAB_05037
PATRICifig|1016998.12.peg.4728

Similar proteinsi

Entry informationi

Entry nameiCDH_SALPB
AccessioniPrimary (citable) accession number: A9MZF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health