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Protein

Probable crotonobetaine/carnitine-CoA ligase

Gene

caiC

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Enzyme and pathway databases

BioCyciSENT28901:GH9O-86-MONOMER.
UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable crotonobetaine/carnitine-CoA ligaseUniRule annotation (EC:6.2.1.-UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
Ordered Locus Names:SPAB_00087
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000875721 – 517Probable crotonobetaine/carnitine-CoA ligaseAdd BLAST517

Structurei

3D structure databases

ProteinModelPortaliA9MYJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230001.
KOiK02182.
OMAiPYVHEFE.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9MYJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIVGGQNLR QMWDDLAGVY GDKTALIFES CEGIVRQFSY ASLNEEINRT
60 70 80 90 100
ANLFYSLGIR KGDRVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLGEE
110 120 130 140 150
SAWILQNSQV SLLVTSAQFY PMYREIRQDN STPLNHICLI GEQLPADDGV
160 170 180 190 200
SHFTQRQSRQ STTLCYTPAL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQIA LRDDDVYMTV MPAFHIDCQC TAAMPAFSAG STFVLLEKYS
260 270 280 290 300
ARAFWDQVRK YQATVTECIP MMIRTLMVQP AAPTDRQHHL REVMFYLNLS
310 320 330 340 350
AQEKDAFTER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRVGFSYE
360 370 380 390 400
AEIRDDQNRP LPAGEIGEIC IKGIPGKTIF KEYYMQPEAT ARALEPEGWL
410 420 430 440 450
HTGDSGYQDE DGYFYFVDRR CNMIKRGGEN VSCVELENII SAHPKIQDIV
460 470 480 490 500
VVGIKDAIRD EAIKAFIVLN EGETLSEAEF FSFCENNMAK FKVPSFMEIR
510
TDLPRNCSGK IIKKNLK
Length:517
Mass (Da):58,475
Last modified:February 5, 2008 - v1
Checksum:i5C40ECA483952FD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX65530.1.
RefSeqiWP_000355811.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX65530; ABX65530; SPAB_00087.
KEGGispq:SPAB_00087.
PATRICi18528357. VBISalEnt120821_0075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX65530.1.
RefSeqiWP_000355811.1. NC_010102.1.

3D structure databases

ProteinModelPortaliA9MYJ6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX65530; ABX65530; SPAB_00087.
KEGGispq:SPAB_00087.
PATRICi18528357. VBISalEnt120821_0075.

Phylogenomic databases

HOGENOMiHOG000230001.
KOiK02182.
OMAiPYVHEFE.

Enzyme and pathway databases

UniPathwayiUPA00117.
BioCyciSENT28901:GH9O-86-MONOMER.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAIC_SALPB
AccessioniPrimary (citable) accession number: A9MYJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.