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Protein

Periplasmic trehalase

Gene

treA

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.UniRule annotation

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159SubstrateUniRule annotation1
Binding sitei203SubstrateUniRule annotation1
Binding sitei317Substrate; via carbonyl oxygenUniRule annotation1
Active sitei319Proton donor/acceptorUniRule annotation1
Active sitei503Proton donor/acceptorUniRule annotation1
Binding sitei518SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSENT1016998:G1GAK-1225-MONOMER

Protein family/group databases

CAZyiGH37 Glycoside Hydrolase Family 37

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic trehalaseUniRule annotation (EC:3.2.1.28UniRule annotation)
Alternative name(s):
Alpha,alpha-trehalaseUniRule annotation
Alpha,alpha-trehalose glucohydrolaseUniRule annotation
Gene namesi
Name:treAUniRule annotation
Ordered Locus Names:SPAB_01423
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Periplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34UniRule annotationAdd BLAST34
ChainiPRO_100008445935 – 570Periplasmic trehalaseAdd BLAST536

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9MVX4
SMRiA9MVX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 167Substrate bindingUniRule annotation2
Regioni212 – 214Substrate bindingUniRule annotation3
Regioni284 – 286Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000215464
KOiK01194
OMAiKYDISNG

Family and domain databases

Gene3Di1.50.10.10, 1 hit
HAMAPiMF_01060 Peripl_trehalase, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001661 Glyco_hydro_37
IPR018232 Glyco_hydro_37_CS
IPR023720 Trehalase_periplasmic
PANTHERiPTHR23403 PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204 Trehalase, 1 hit
PRINTSiPR00744 GLHYDRLASE37
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00927 TREHALASE_1, 1 hit
PS00928 TREHALASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A9MVX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPEIRRSV LLQKAIKLAL AGTLLTFASF SATAADPSSD TETPQPPDIL
60 70 80 90 100
LGPLFNDVQN AKLFPDQKTF ADAIPNSDPL MILADYRMQR NQSGFDLRHF
110 120 130 140 150
VDVNFTLPKA GEKYVPPAGQ SLREHIDGLW PVLTRSTKNV EKWDSLLPLP
160 170 180 190 200
ESYVVPGGRF REIYYWDSYF TMLGLAESGH WDKVADMVAN FGYEIDAWGH
210 220 230 240 250
IPNGNRTYYL SRSQPPFFAF MVELLAQHEG DDALKEYLPQ LQKEYAYWME
260 270 280 290 300
GVETLQPGQQ NQRVVKLEDG SVLNRYWDDR DTPRPESWVE DIATAKSNPN
310 320 330 340 350
RPATEIYRDL RSAAASGWDF SSRWMDNPQQ LSTIRTTTIV PVDLNALLYQ
360 370 380 390 400
LEKTLARASA AAGDRAKASH YDALANARQQ AIEMHLWNNK EGWYADYDLK
410 420 430 440 450
NNKIRDQLTA AALFPLYVNA AAKDRAAKVA AAAQAHLLQP GGLATTSVKS
460 470 480 490 500
GQQWDAPNGW APLQWVAAEG LQNYGQDDVA MEVTWRFLTN VQHTYDREKK
510 520 530 540 550
LVEKYDVSST GTGGGGGEYP LQDGFGWTNG VTLKMLDLIC PQEKPCDSVP
560 570
STRPASLSAT PTKTPSAATQ
Length:570
Mass (Da):63,586
Last modified:February 5, 2008 - v1
Checksum:iBB50C61E638929CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX66830.1
RefSeqiWP_000612826.1, NC_010102.1

Genome annotation databases

EnsemblBacteriaiABX66830; ABX66830; SPAB_01423
KEGGispq:SPAB_01423
PATRICifig|1016998.12.peg.1342

Similar proteinsi

Entry informationi

Entry nameiTREA_SALPB
AccessioniPrimary (citable) accession number: A9MVX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health