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Protein

Periplasmic trehalase

Gene

treA

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.UniRule annotation

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591SubstrateUniRule annotation
Binding sitei203 – 2031SubstrateUniRule annotation
Binding sitei317 – 3171Substrate; via carbonyl oxygenUniRule annotation
Active sitei319 – 3191Proton donor/acceptorUniRule annotation
Active sitei503 – 5031Proton donor/acceptorUniRule annotation
Binding sitei518 – 5181SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSENT28901:GH9O-1421-MONOMER.

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic trehalaseUniRule annotation (EC:3.2.1.28UniRule annotation)
Alternative name(s):
Alpha,alpha-trehalaseUniRule annotation
Alpha,alpha-trehalose glucohydrolaseUniRule annotation
Gene namesi
Name:treAUniRule annotation
Ordered Locus Names:SPAB_01423
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Periplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434UniRule annotationAdd
BLAST
Chaini35 – 570536Periplasmic trehalasePRO_1000084459Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9MVX4.
SMRiA9MVX4. Positions 44-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1672Substrate bindingUniRule annotation
Regioni212 – 2143Substrate bindingUniRule annotation
Regioni284 – 2863Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000215464.
KOiK01194.
OMAiWAGQLHQ.
OrthoDBiEOG6CCH1S.

Family and domain databases

HAMAPiMF_01060. Peripl_trehalase.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
IPR023720. Trehalase_periplasmic.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A9MVX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPEIRRSV LLQKAIKLAL AGTLLTFASF SATAADPSSD TETPQPPDIL
60 70 80 90 100
LGPLFNDVQN AKLFPDQKTF ADAIPNSDPL MILADYRMQR NQSGFDLRHF
110 120 130 140 150
VDVNFTLPKA GEKYVPPAGQ SLREHIDGLW PVLTRSTKNV EKWDSLLPLP
160 170 180 190 200
ESYVVPGGRF REIYYWDSYF TMLGLAESGH WDKVADMVAN FGYEIDAWGH
210 220 230 240 250
IPNGNRTYYL SRSQPPFFAF MVELLAQHEG DDALKEYLPQ LQKEYAYWME
260 270 280 290 300
GVETLQPGQQ NQRVVKLEDG SVLNRYWDDR DTPRPESWVE DIATAKSNPN
310 320 330 340 350
RPATEIYRDL RSAAASGWDF SSRWMDNPQQ LSTIRTTTIV PVDLNALLYQ
360 370 380 390 400
LEKTLARASA AAGDRAKASH YDALANARQQ AIEMHLWNNK EGWYADYDLK
410 420 430 440 450
NNKIRDQLTA AALFPLYVNA AAKDRAAKVA AAAQAHLLQP GGLATTSVKS
460 470 480 490 500
GQQWDAPNGW APLQWVAAEG LQNYGQDDVA MEVTWRFLTN VQHTYDREKK
510 520 530 540 550
LVEKYDVSST GTGGGGGEYP LQDGFGWTNG VTLKMLDLIC PQEKPCDSVP
560 570
STRPASLSAT PTKTPSAATQ
Length:570
Mass (Da):63,586
Last modified:February 5, 2008 - v1
Checksum:iBB50C61E638929CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX66830.1.
RefSeqiWP_000612826.1. NC_010102.1.

Genome annotation databases

EnsemblBacteriaiABX66830; ABX66830; SPAB_01423.
KEGGispq:SPAB_01423.
PATRICi18530590. VBISalEnt120821_1171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA. Translation: ABX66830.1.
RefSeqiWP_000612826.1. NC_010102.1.

3D structure databases

ProteinModelPortaliA9MVX4.
SMRiA9MVX4. Positions 44-554.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX66830; ABX66830; SPAB_01423.
KEGGispq:SPAB_01423.
PATRICi18530590. VBISalEnt120821_1171.

Phylogenomic databases

HOGENOMiHOG000215464.
KOiK01194.
OMAiWAGQLHQ.
OrthoDBiEOG6CCH1S.

Enzyme and pathway databases

BioCyciSENT28901:GH9O-1421-MONOMER.

Family and domain databases

HAMAPiMF_01060. Peripl_trehalase.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
IPR023720. Trehalase_periplasmic.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1250 / SPB7.

Entry informationi

Entry nameiTREA_SALPB
AccessioniPrimary (citable) accession number: A9MVX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 11, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.