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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.UniRule annotation

Enzyme regulationi

Activated by ATP and maltotriose, which are both required for DNA binding.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8
DNA bindingi853 – 872H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCarbohydrate metabolism, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:SPAB_04376
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000857771 – 901HTH-type transcriptional regulator MalTAdd BLAST901

Proteomic databases

PRIDEiA9MTT7

Interactioni

Subunit structurei

Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9MTT7
SMRiA9MTT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini829 – 894HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the MalT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218261
KOiK03556
OMAiSDWVSNA

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
HAMAPiMF_01247 HTH_type_MalT, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR023768 Tscrpt_reg_HTH_MalT
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9MTT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALVTSP AGYGKTTLVS
60 70 80 90 100
QWAAGKNELG WYSLDEGDNQ QERFASYLIA AIQQATGGHC STSEAMAQKR
110 120 130 140 150
QYASLTSLFA QLFIELAQWH RPLYLVIDDY HLITNPVIHD AMRFFLRHQP
160 170 180 190 200
ENFTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFNHQE AKQFFDRRLS
210 220 230 240 250
SPIEAAESSR MCDDVAGWAT ALQLIALSAR QNHTSAHHSA RRLAGINASH
260 270 280 290 300
LSDYLVDEVL DNVDVSTRHF LLKSAILRSM NDALIVRVTG EENGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDTGEWFSY HPLFGSFLRQ RCQWELAAEL PEIHRAAAES
360 370 380 390 400
WMEQGFPSEA IHHALAAGDA QMLRDILLNH AWGLFNHSEL ALLEESLKAL
410 420 430 440 450
PWESLLENPR LVLLQAWLMQ SQHRYSEVNT LLARAEQEIK GVMDGTLHAE
460 470 480 490 500
FNALRAQVAI NDGNPEEAER LAKLALDELP LAWFYSRIVA TSVHGEVLHC
510 520 530 540 550
KGDLSQSLSL MQQTEQMARH HDVWHYALWS LIQQSEIQFA QGFLQAAWET
560 570 580 590 600
QERAFQLIKE QHLEQLPMHE FLVRIRAQLL WAWARLDEAE ASARSGIAVL
610 620 630 640 650
STFQPQQQLQ CLTLLVQCSL ARGDLDNARS QLNRLENLLG NGRYHCDWIS
660 670 680 690 700
NADKVRVIYW QLTGDKKSAA NWLRHTPKPA FANNHFLQGQ WRNIARAQIL
710 720 730 740 750
LGEFEPAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ SGRKNDAQRV
760 770 780 790 800
LLDALQLANR TGFISHFVIE GEAMAQQLRQ LIQLNTLPEM EQHRAQRILR
810 820 830 840 850
EINQHHRHKF AHFDEGFVER LLNHPDVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL AVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG

V
Length:901
Mass (Da):103,016
Last modified:February 5, 2008 - v1
Checksum:iA85BD13270CA3366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX69692.1
RefSeqiWP_000907030.1, NC_010102.1

Genome annotation databases

EnsemblBacteriaiABX69692; ABX69692; SPAB_04376
KEGGispq:SPAB_04376
PATRICifig|1016998.12.peg.4119

Similar proteinsi

Entry informationi

Entry nameiMALT_SALPB
AccessioniPrimary (citable) accession number: A9MTT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health