Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188S-adenosyl-L-methionineUniRule annotation1
Binding sitei240S-adenosyl-L-methionineUniRule annotation1
Binding sitei260S-adenosyl-L-methionineUniRule annotation1
Binding sitei277S-adenosyl-L-methionineUniRule annotation1
Active sitei306Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:SARI_04682
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002084 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000877371 – 366Ribosomal RNA large subunit methyltransferase MAdd BLAST366

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi882884.SARI_04682.

Structurei

3D structure databases

ProteinModelPortaliA9MSA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni221 – 224S-adenosyl-L-methionine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiPOG091H04R8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A9MSA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVVLLCRP GFEKECAAEI TDKAGKRELF GFARVKENTG YVIYECYQPE
60 70 80 90 100
DGEKLISELP FSSLIFARQW FVVGELLQHL PPEDRITPIV GMLQGVVEKG
110 120 130 140 150
GELRVEVADT NESKELMKFC RKFTVPLRAA LRDAGVLTHY ETPKRPVVHV
160 170 180 190 200
FFIAPGCCYT GYSLAHNHSP FYMGIPRLKF PSDAPSRSTL KLEEALHVFI
210 220 230 240 250
PEDEWDERLA NGMYAVDLGA CPGGWTYQLV KRNMWVYSVD NGPMAQSLMD
260 270 280 290 300
TGQVTWLRED GFRYRPNRNN ISWMVCDMVE KPAKVTALMA QWLVNGWCRE
310 320 330 340 350
TIFNLKLPMK KRYEEVSHNL AYLQAQLDEH GVNAQIQARQ LYHDREEVTV
360
HVRRLWAAVG GRRDER
Length:366
Mass (Da):42,062
Last modified:February 5, 2008 - v1
Checksum:iF5CE1B63C5203B43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA. Translation: ABX24446.1.
RefSeqiWP_001045501.1. NC_010067.1.

Genome annotation databases

EnsemblBacteriaiABX24446; ABX24446; SARI_04682.
KEGGises:SARI_04682.
PATRICi18478278. VBISalEnt13497_4435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA. Translation: ABX24446.1.
RefSeqiWP_001045501.1. NC_010067.1.

3D structure databases

ProteinModelPortaliA9MSA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882884.SARI_04682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX24446; ABX24446; SARI_04682.
KEGGises:SARI_04682.
PATRICi18478278. VBISalEnt13497_4435.

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiPOG091H04R8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMM_SALAR
AccessioniPrimary (citable) accession number: A9MSA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.