Reviewed,
UniProtKB/Swiss-Prot A9MQA3 (GUAC_SALAR)
Last modified
February 9, 2010.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GMP reductase EC=1.7.1.7 Alternative name(s): Guanosine 5'-monophosphate oxidoreductase Short name=Guanosine monophosphate reductase | ||||
| Gene names |
| ||||
| Organism | Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 41514 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 347 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_00596 |
| Catalytic activity | Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_00596 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_00596 |
| Sequence similarities | Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding NADP Potassium |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine nucleotide metabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | GMP reductase activity Inferred from electronic annotation. Source: HAMAP potassium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 347 | 347 | GMP reductase HAMAP MF_00596 | PRO_1000082439 | |||||
Regions | |||||||||
| Nucleotide binding | 108 – 131 | 24 | NADP By similarity | ||||||
| Nucleotide binding | 216 – 239 | 24 | NADP; ribose moiety By similarity | ||||||
Sites | |||||||||
| Active site | 186 | 1 | Thioimidate intermediate By similarity | ||||||
| Metal binding | 181 | 1 | Potassium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 183 | 1 | Potassium; via carbonyl oxygen By similarity | ||||||
Sequences
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References
| [1] | McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000880 Genomic DNA. Translation: ABX22701.1. |
| RefSeq | YP_001571843.1. |
3D structure databases | |
| SMR | A9MQA3. Positions 3-338. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5762929. |
| GenomeReviews | Gene locus SARI_02854 in contig CP000880_GR. |
| KEGG | ses:SARI_02854. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG298985. |
| OMA | FRNSKQM. |
Family and domain databases | |
| HAMAP | MF_00596. GMP_reduct_type1. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF00478. IMPDH. 1 hit. [Graphical view] |
| PIRSF | PIRSF000235. GMP_reductase. 1 hit. |
| TIGRFAMs | TIGR01305. GMP_reduct_1. 1 hit. |
| PROSITE | PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAC_SALAR | ||||||||
| Accession | Primary (citable) accession number: A9MQA3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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