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A9MQ82

- BGAL_SALAR

UniProt

A9MQ82 - BGAL_SALAR

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Protein
Beta-galactosidase
Gene
lacZ, SARI_02832
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation
Binds 1 sodium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Substrate By similarity
Metal bindingi202 – 2021Sodium By similarity
Binding sitei202 – 2021Substrate By similarity
Sitei358 – 3581Transition state stabilizer By similarity
Sitei392 – 3921Transition state stabilizer By similarity
Metal bindingi417 – 4171Magnesium 1 By similarity
Metal bindingi419 – 4191Magnesium 1 By similarity
Active sitei462 – 4621Proton donor By similarity
Metal bindingi462 – 4621Magnesium 1 By similarity
Binding sitei462 – 4621Substrate By similarity
Active sitei538 – 5381Nucleophile By similarity
Metal bindingi598 – 5981Magnesium 2 By similarity
Metal bindingi602 – 6021Sodium; via carbonyl oxygen By similarity
Metal bindingi605 – 6051Sodium By similarity
Binding sitei605 – 6051Substrate By similarity
Binding sitei1003 – 10031Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:SARI_02832
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002084: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10251025Beta-galactosidaseUniRule annotation
PRO_0000367007Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi41514.SARI_02832.

Structurei

3D structure databases

ProteinModelPortaliA9MQ82.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni538 – 5414Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9MQ82-1 [UniParc]FASTAAdd to Basket

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MTPERDSLAA VLARRDWENP AVTQFNRLTA HPPFCSWRKA DDAQRNQYAA     50
QIRSLNGVWK FAWFSSPQAV PENWRLEDLT EAGTINVPSN WQMYGYDSPI 100
YSNITYPFPV NPPCVPAENP TGCYSLTFCM DDDWLTEGQT RIIFDGVNSA 150
FHLWCNGRWV GYGQDSRLPS EFDLSEYLQV GENRLAVLVL RWSDGSYLED 200
QDMWRMSGIF RDVSLLHKPT TQITDFHLHT HLNDDFTQAV LEAEVRLAGG 250
VNDDLQLVLH LWQGETLAGE ARATPGSEII DERGGYDDRA TLRLNINRPA 300
LWSAETPNLY RAVIQLRTAD GELIEAEACD VGFRQVRIDK GLLLLNGKPL 350
LIRGTNRHEH HPERGQVMDY DTMVQDILLM KQNNFNAVRC SHYPNHPQWY 400
ALCDRYGLYV VDEANIETHG MTPMNRLSDD PDWLPAMSQR VTRMVQRDRN 450
HPSIIIWSLG NESGHGANHD ALYRWLKAED PSRPVQYEGG GADTAATDII 500
CPMYARVDQD QPFPAVPKWS IKKWLSLPGE QRPLILCEYA HAMGNSFGGF 550
AKYWQAFRQY PRLQGGFVWD WVDQSLIKYD ADGKPWSAYG GDFGDTPNDR 600
QFCMNGLVFA DRTPHPALYE AKHVQQFFQF RLLPGEERRI EVQSEYLFRH 650
SDNEILRWML AQEGNQLASG EVVLDIAPQG RQIILLPAFP QPETAGQLWL 700
TVRVEQPLAT SWSEAGHISA WQQWPLEEKL CVSKPTRASV APVLTMRDGE 750
FCVTQGNLRW QFCRQQGWLT QFWRDDEAQL LTPLIDQFTR APLDNDIGVS 800
EATRIDPNAW VERWKAAGHY CAEPALLLCD ADELADAVLI TTAHAWQYQG 850
ATLFISRKTY RIDDHGEMQI DIGVEVASGM PYPARIGLSC QLAQVNERVE 900
WLGLGPHENY PDRLSSACFD RWNLPLDAMY TPYVFPTENG LRCGTRQLRY 950
GAHQWSGDFQ FNISRYSQRQ LMETSHRHLL QAEAGVWLNI DGYHMGVGGD 1000
DSWSPSVSPE FQLSARHYHY QIAWK 1025
Length:1,025
Mass (Da):117,238
Last modified:March 24, 2009 - v2
Checksum:iE76A52C51D8A95B7
GO

Sequence cautioni

The sequence ABX22680.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000880 Genomic DNA. Translation: ABX22680.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABX22680; ABX22680; SARI_02832.
PATRICi18474706. VBISalEnt13497_2701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000880 Genomic DNA. Translation: ABX22680.1 . Different initiation.

3D structure databases

ProteinModelPortali A9MQ82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41514.SARI_02832.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX22680 ; ABX22680 ; SARI_02832 .
PATRICi 18474706. VBISalEnt13497_2701.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
OrthoDBi EOG6XWV0T.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Entry informationi

Entry nameiBGAL_SALAR
AccessioniPrimary (citable) accession number: A9MQ82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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