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A9MPW6

- RIBB_SALAR

UniProt

A9MPW6 - RIBB_SALAR

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Protein
3,4-dihydroxy-2-butanone 4-phosphate synthase
Gene
ribB, SARI_04433
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity.UniRule annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Magnesium or manganese 1 By similarity
Metal bindingi38 – 381Magnesium or manganese 2 By similarity
Binding sitei42 – 421Substrate By similarity
Sitei136 – 1361Essential for catalytic activity By similarity
Metal bindingi153 – 1531Magnesium or manganese 2 By similarity
Binding sitei174 – 1741Substrate By similarity
Sitei174 – 1741Essential for catalytic activity By similarity

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT882884:GJ8H-4425-MONOMER.
UniPathwayiUPA00275; UER00399.

Names & Taxonomyi

Protein namesi
Recommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase (EC:4.1.99.12)
Short name:
DHBP synthase
Gene namesi
Name:ribB
Ordered Locus Names:SARI_04433
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002084: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2172173,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation
PRO_1000077266Add
BLAST

Proteomic databases

PRIDEiA9MPW6.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi41514.SARI_04433.

Structurei

3D structure databases

ProteinModelPortaliA9MPW6.
SMRiA9MPW6. Positions 1-217.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 382Substrate binding By similarity
Regioni150 – 1545Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHBP synthase family.

Phylogenomic databases

eggNOGiCOG0108.
HOGENOMiHOG000115444.
OMAiQMAKLIR.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

A9MPW6-1 [UniParc]FASTAAdd to Basket

« Hide

MNQTLLSSFG TPFERVELAL DALREGRGVM VLDDEDRENE GDMIFPAETM    50
TVEQMALTIR HGSGIVCLCI TEDRRKQLDL PMMVQNNTSA YGTGFTVTIE 100
AAEGVTTGVS AADRVTTVRA AIADGAKPSD LNRPGHVFPL RAQAGGVLTR 150
GGHTEATIDL MTLAGFKPAG VLCELTNDNG TMARAPECIA FAGQHNMAVV 200
TIEDLVAYRL AHERKVS 217
Length:217
Mass (Da):23,264
Last modified:February 5, 2008 - v1
Checksum:iFB943563305B57C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000880 Genomic DNA. Translation: ABX24209.1.

Genome annotation databases

EnsemblBacteriaiABX24209; ABX24209; SARI_04433.
PATRICi18477808. VBISalEnt13497_4204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000880 Genomic DNA. Translation: ABX24209.1 .

3D structure databases

ProteinModelPortali A9MPW6.
SMRi A9MPW6. Positions 1-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41514.SARI_04433.

Proteomic databases

PRIDEi A9MPW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX24209 ; ABX24209 ; SARI_04433 .
PATRICi 18477808. VBISalEnt13497_4204.

Phylogenomic databases

eggNOGi COG0108.
HOGENOMi HOG000115444.
OMAi QMAKLIR.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
BioCyci SENT882884:GJ8H-4425-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00180. RibB.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Entry informationi

Entry nameiRIBB_SALAR
AccessioniPrimary (citable) accession number: A9MPW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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