Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A9MPW6

- RIBB_SALAR

UniProt

A9MPW6 - RIBB_SALAR

Protein

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene

ribB

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotation

    Catalytic activityi

    D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Magnesium or manganese 1UniRule annotation
    Metal bindingi38 – 381Magnesium or manganese 2UniRule annotation
    Binding sitei42 – 421SubstrateUniRule annotation
    Sitei136 – 1361Essential for catalytic activityUniRule annotation
    Metal bindingi153 – 1531Magnesium or manganese 2UniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Sitei174 – 1741Essential for catalytic activityUniRule annotation

    GO - Molecular functioni

    1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT882884:GJ8H-4425-MONOMER.
    UniPathwayiUPA00275; UER00399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation (EC:4.1.99.12UniRule annotation)
    Short name:
    DHBP synthaseUniRule annotation
    Gene namesi
    Name:ribBUniRule annotation
    Ordered Locus Names:SARI_04433
    OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
    Taxonomic identifieri41514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002084: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2172173,4-dihydroxy-2-butanone 4-phosphate synthasePRO_1000077266Add
    BLAST

    Proteomic databases

    PRIDEiA9MPW6.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi41514.SARI_04433.

    Structurei

    3D structure databases

    ProteinModelPortaliA9MPW6.
    SMRiA9MPW6. Positions 1-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 382Substrate bindingUniRule annotation
    Regioni150 – 1545Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DHBP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0108.
    HOGENOMiHOG000115444.
    OMAiQMAKLIR.
    OrthoDBiEOG679TK8.

    Family and domain databases

    Gene3Di3.90.870.10. 1 hit.
    HAMAPiMF_00180. RibB.
    InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    [Graphical view]
    PfamiPF00926. DHBP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55821. SSF55821. 1 hit.
    TIGRFAMsiTIGR00506. ribB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9MPW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQTLLSSFG TPFERVELAL DALREGRGVM VLDDEDRENE GDMIFPAETM    50
    TVEQMALTIR HGSGIVCLCI TEDRRKQLDL PMMVQNNTSA YGTGFTVTIE 100
    AAEGVTTGVS AADRVTTVRA AIADGAKPSD LNRPGHVFPL RAQAGGVLTR 150
    GGHTEATIDL MTLAGFKPAG VLCELTNDNG TMARAPECIA FAGQHNMAVV 200
    TIEDLVAYRL AHERKVS 217
    Length:217
    Mass (Da):23,264
    Last modified:February 5, 2008 - v1
    Checksum:iFB943563305B57C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX24209.1.

    Genome annotation databases

    EnsemblBacteriaiABX24209; ABX24209; SARI_04433.
    PATRICi18477808. VBISalEnt13497_4204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX24209.1 .

    3D structure databases

    ProteinModelPortali A9MPW6.
    SMRi A9MPW6. Positions 1-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41514.SARI_04433.

    Proteomic databases

    PRIDEi A9MPW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX24209 ; ABX24209 ; SARI_04433 .
    PATRICi 18477808. VBISalEnt13497_4204.

    Phylogenomic databases

    eggNOGi COG0108.
    HOGENOMi HOG000115444.
    OMAi QMAKLIR.
    OrthoDBi EOG679TK8.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00399 .
    BioCyci SENT882884:GJ8H-4425-MONOMER.

    Family and domain databases

    Gene3Di 3.90.870.10. 1 hit.
    HAMAPi MF_00180. RibB.
    InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    [Graphical view ]
    Pfami PF00926. DHBP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55821. SSF55821. 1 hit.
    TIGRFAMsi TIGR00506. ribB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

    Entry informationi

    Entry nameiRIBB_SALAR
    AccessioniPrimary (citable) accession number: A9MPW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3