A9MNS4 (A9MNS4_SALAR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoheptose isomerase HAMAP-Rule MF_00067
EC=5.3.1.28 HAMAP-Rule MF_00067

Alternative name(s):
Sedoheptulose 7-phosphate isomerase HAMAP-Rule MF_00067

Gene names

Name:	gmhA HAMAP-Rule MF_00067
Ordered Locus Names:	SARI_02700

Organism

Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP] EMBL ABX22556.1

Taxonomic identifier

41514 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica subsp. arizonae

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067
Catalytic activity	D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. SAAS SAAS004515 HAMAP-Rule MF_00067
Cofactor	Binds 1 zinc ion per subunit By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067
Pathway	Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. SAAS SAAS004515 HAMAP-Rule MF_00067
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00067
Subcellular location	Cytoplasm By similarity SAAS SAAS004515 HAMAP-Rule MF_00067.
Miscellaneous	The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP-Rule MF_00067
Sequence similarities	Belongs to the SIS family. GmhA subfamily. HAMAP-Rule MF_00067 Contains 1 SIS domain. SAAS SAAS004515 HAMAP-Rule MF_00067

Ontologies

Keywords
Biological process	Carbohydrate metabolism SAAS SAAS004515 HAMAP-Rule MF_00067
Cellular component	Cytoplasm SAAS SAAS004515 HAMAP-Rule MF_00067
Ligand	Metal-binding SAAS SAAS004515 HAMAP-Rule MF_00067 Zinc SAAS SAAS004515 HAMAP-Rule MF_00067
Molecular function	Isomerase SAAS SAAS004515 HAMAP-Rule MF_00067
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-glycero-D-manno-heptose 7-phosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway lipopolysaccharide core region biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	D-sedoheptulose 7-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP carbohydrate binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	43 – 198	156	SIS By similarity HAMAP-Rule MF_00067
	Region	58 – 60	3	Substrate binding By similarity HAMAP-Rule MF_00067
	Region	99 – 100	2	Substrate binding By similarity HAMAP-Rule MF_00067
	Region	125 – 127	3	Substrate binding By similarity HAMAP-Rule MF_00067
Sites
	Metal binding	67	1	Zinc By similarity HAMAP-Rule MF_00067
	Metal binding	71	1	Zinc By similarity HAMAP-Rule MF_00067
	Metal binding	178	1	Zinc By similarity HAMAP-Rule MF_00067
	Metal binding	186	1	Zinc By similarity HAMAP-Rule MF_00067
	Binding site	71	1	Substrate By similarity HAMAP-Rule MF_00067
	Binding site	130	1	Substrate By similarity HAMAP-Rule MF_00067
	Binding site	178	1	Substrate By similarity HAMAP-Rule MF_00067

Sequences

	Sequence		Length	Mass (Da)
	A9MNS4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: D9BC1196BFDBA83A	FASTA	198	21,610
	10 20 30 40 50 60 MLKDILMYQD LIRNELNEAA ETLANFLKDD ANIHAIQRAA VLLADSFKAG GKVLSCGNGG 70 80 90 100 110 120 SHCDAMHFAE ELTGRYRENR PGYPAIAISD VSHISCVSND FGYDYIFSRY VEAVGREGDV 130 140 150 160 170 180 LLGISTSGNS GNVIKAIAAA REKGMKVITL TGKDGGKMAG TADIEIRVPH FGYADRIQEI 190 HIKVIHILIQ LIEKEMVK

References

[1]

The Salmonella enterica serovar Arizonae Genome Sequencing Project McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000880 Genomic DNA. Translation: ABX22556.1.
RefSeq	YP_001571698.1. NC_010067.1.
3D structure databases
ProteinModelPortal	A9MNS4.
SMR	A9MNS4. Positions 7-198.
ModBase	Search...
Protein-protein interaction databases
STRING	41514.SARI_02700.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX22556; ABX22556; SARI_02700.
GeneID	5762488.
KEGG	ses:SARI_02700.
PATRIC	18474448. VBISalEnt13497_2579.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0279.
HOGENOM	HOG000237571.
KO	K03271.
OMA	FLAHKEA.
ProtClustDB	PRK00414.
Enzyme and pathway databases
BioCyc	SENT882884:GJ8H-2696-MONOMER.
UniPathway	UPA00041; UER00436.
Family and domain databases
HAMAP	MF_00067. GmhA.
InterPro	IPR004515. Phosphoheptose_Isoase. IPR001347. SIS. [Graphical view]
Pfam	PF13580. SIS_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00441. gmhA. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9MNS4_SALAR

Accession

Primary (citable) accession number: A9MNS4

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)