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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.UniRule annotation

Enzyme regulationi

Activated by ATP and maltotriose, which are both required for DNA binding.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8
DNA bindingi853 – 872H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCarbohydrate metabolism, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:SARI_04099
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002084 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000857741 – 901HTH-type transcriptional regulator MalTAdd BLAST901

Proteomic databases

PRIDEiA9MMA9

Interactioni

Subunit structurei

Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi882884.SARI_04099

Structurei

3D structure databases

ProteinModelPortaliA9MMA9
SMRiA9MMA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini829 – 894HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the MalT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR Bacteria
COG2909 LUCA
HOGENOMiHOG000218261
KOiK03556
OMAiSDWVSNA
OrthoDBiPOG091H0FN0

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
HAMAPiMF_01247 HTH_type_MalT, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR023768 Tscrpt_reg_HTH_MalT
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9MMA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALVTSP AGYGKTTLVS
60 70 80 90 100
QWAAGKNELG WFSLDEGDNQ QERFASYLIA AIQQATGGHC TTSEAMAQKR
110 120 130 140 150
QYASLTSLFA QLFIELAQWH RPLYLVIDDY HLITNPVIHD AMRFFLRHQP
160 170 180 190 200
ENFTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFNHQE AKQFFDRRLS
210 220 230 240 250
SPIEAAESSR MCDDVAGWAT ALQLIALSAR QNNHSAHQSA RRLAGINASH
260 270 280 290 300
LSDYLVDEVL DNVDVSTRHF LLKSAILRSM NDALIVRVTG EENGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDTGEWFSY HPLFGSFLRQ RCQWELTAEL PGIHRSAAES
360 370 380 390 400
WMEQGFPSEA IHHALAAGDA QMLRDILLNH AWRLFNHSEL ALLEESLKAL
410 420 430 440 450
PWESLLENPR LVLLQAWLMQ SQHRYSEVNT LLARAEQEIK GVMDGTLHAE
460 470 480 490 500
FNALRAQVAI NDGNPEEAER LAKLALDELP LAWFYSRIVA TSVHGEVLHC
510 520 530 540 550
KGDLSQSLSL MQQTEQMARH HDVWHYALWS LIQQSEIQFA QGFLQAAWET
560 570 580 590 600
QERAFQLIKE QHLEQLPMHE FLVRIRAQLL WAWARLDEAE ASARSGIAVL
610 620 630 640 650
STFQPQQQLQ CLTLLVQCSL ARGDLDNARS QLNRLENLLG NGRYHCDWIS
660 670 680 690 700
NADKVRVIYW QLTGDKKSAA NWLRHTPKPA FANNHFLQGQ WRNIARAQIL
710 720 730 740 750
LGEFEPAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ SGRKTDAQRV
760 770 780 790 800
LLDALQLANR TGFISHFVIE GEAMAQQLRQ LIQLNTLPEM EQHRAQRILR
810 820 830 840 850
EINQHHRHKF AHFDEGFVER LLNHPDVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL AVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG

V
Length:901
Mass (Da):103,078
Last modified:February 5, 2008 - v1
Checksum:i4A445F83AAE8D089
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA Translation: ABX23888.1
RefSeqiWP_000907021.1, NC_010067.1

Genome annotation databases

EnsemblBacteriaiABX23888; ABX23888; SARI_04099
KEGGises:SARI_04099

Similar proteinsi

Entry informationi

Entry nameiMALT_SALAR
AccessioniPrimary (citable) accession number: A9MMA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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