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Protein

Ferrochelatase

Gene

hemH

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi194 – 1941IronUniRule annotation
Metal bindingi275 – 2751IronUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSENT882884:GJ8H-2441-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:SARI_02445
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002084 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320FerrochelatasePRO_1000079200Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi882884.SARI_02445.

Structurei

3D structure databases

ProteinModelPortaliA9MLY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFX. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060730.
KOiK01772.
OMAiWEEGSPL.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9MLY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQTKTGILL ANLGTPDAPT PEAVKRYLKQ FLSDRRVVDT PRPLWWPLLR
60 70 80 90 100
GVILPLRSPR VAKLYQSIWM DGGSPLMVYS REQQQGLAAR LPDTPVALGM
110 120 130 140 150
SYGSPSLESA VDELLASDVD HIVVLPLYPQ YSCSTVGAVW DELGRILARK
160 170 180 190 200
RRIPGISFIR DYADDGAYID ALAKSARESF ARHGEPDLLL LSYHGIPQRY
210 220 230 240 250
ADEGDDYPQR CRDTTRELVS ALGLPPEKVM MTFQSRFGRE PWLTPYTDET
260 270 280 290 300
LKMLGEKGTG HIQVMCPGFA ADCLETLEEI AEQNREIFLE AGGKKYAYIP
310 320
ALNATPEHID MMLKLTAPYR
Length:320
Mass (Da):35,898
Last modified:February 5, 2008 - v1
Checksum:i122B9380B7E84719
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA. Translation: ABX22306.1.
RefSeqiWP_001250085.1. NC_010067.1.

Genome annotation databases

EnsemblBacteriaiABX22306; ABX22306; SARI_02445.
KEGGises:SARI_02445.
PATRICi18473986. VBISalEnt13497_2349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA. Translation: ABX22306.1.
RefSeqiWP_001250085.1. NC_010067.1.

3D structure databases

ProteinModelPortaliA9MLY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882884.SARI_02445.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX22306; ABX22306; SARI_02445.
KEGGises:SARI_02445.
PATRICi18473986. VBISalEnt13497_2349.

Phylogenomic databases

eggNOGiENOG4105CFX. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060730.
KOiK01772.
OMAiWEEGSPL.
OrthoDBiEOG6XHC5H.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciSENT882884:GJ8H-2441-MONOMER.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Entry informationi

Entry nameiHEMH_SALAR
AccessioniPrimary (citable) accession number: A9MLY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.