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A9MLS8

- COBT_SALAR

UniProt

A9MLS8 - COBT_SALAR

Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

    Catalytic activityi

    Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei317 – 3171Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
    2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-KW
    2. nucleoside biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis

    Enzyme and pathway databases

    BioCyciSENT882884:GJ8H-872-MONOMER.
    UniPathwayiUPA00061; UER00516.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
    Short name:
    NN:DBI PRTUniRule annotation
    Alternative name(s):
    N(1)-alpha-phosphoribosyltransferaseUniRule annotation
    Gene namesi
    Name:cobTUniRule annotation
    Ordered Locus Names:SARI_00872
    OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
    Taxonomic identifieri41514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002084: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000078247Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi41514.SARI_00872.

    Structurei

    3D structure databases

    ProteinModelPortaliA9MLS8.
    SMRiA9MLS8. Positions 3-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CobT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2038.
    HOGENOMiHOG000263499.
    OMAiAICSVIT.
    OrthoDBiEOG6HF61K.

    Family and domain databases

    Gene3Di1.10.1610.10. 1 hit.
    HAMAPiMF_00230. CobT.
    InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view]
    PfamiPF02277. DBI_PRT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52733. SSF52733. 1 hit.
    TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9MLS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTLHALLRD IPAPDTDAMA RAQQHIDGLL KPPGSLGRLE ALAVQLAGMP    50
    GLNGTPQVGE KAMLVMCADH GVWDEGVAVS PKIVTAIQAA NMTRGTTGVC 100
    VLAAQAGAKV HVIDVGIDAE PIPGVVNMRV ARGCGNIAVG PAMSRSQAEV 150
    LLLEVIRYTC DLAQRGVTLF GVGELGMANT TPAAAMVSVF TGSDAKEVVG 200
    IGANLPPSRI DNKVDVVRRA IAINQPDPHD GIDVLSKVGG FDLVGMTGVM 250
    LGAARCGLPV LLDGFLSYSA ALAACQIAPA VRSYLIPSHF SAEKGARIAL 300
    AHLAMEPYLH MAMRLGEGSG AALAMPIVEA ACAMFHNMGE LAASNIVLPG 350
    EKQT 354
    Length:354
    Mass (Da):36,501
    Last modified:February 5, 2008 - v1
    Checksum:i1BD7DDC058C5CA6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX20791.1.

    Genome annotation databases

    EnsemblBacteriaiABX20791; ABX20791; SARI_00872.
    PATRICi18470900. VBISalEnt13497_0839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX20791.1 .

    3D structure databases

    ProteinModelPortali A9MLS8.
    SMRi A9MLS8. Positions 3-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41514.SARI_00872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX20791 ; ABX20791 ; SARI_00872 .
    PATRICi 18470900. VBISalEnt13497_0839.

    Phylogenomic databases

    eggNOGi COG2038.
    HOGENOMi HOG000263499.
    OMAi AICSVIT.
    OrthoDBi EOG6HF61K.

    Enzyme and pathway databases

    UniPathwayi UPA00061 ; UER00516 .
    BioCyci SENT882884:GJ8H-872-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1610.10. 1 hit.
    HAMAPi MF_00230. CobT.
    InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view ]
    Pfami PF02277. DBI_PRT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52733. SSF52733. 1 hit.
    TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

    Entry informationi

    Entry nameiCOBT_SALAR
    AccessioniPrimary (citable) accession number: A9MLS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3