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A9MLS8

- COBT_SALAR

UniProt

A9MLS8 - COBT_SALAR

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Protein
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Gene
cobT, SARI_00872
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity.UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei317 – 3171Proton acceptor By similarity

GO - Molecular functioni

  1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
  2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-KW
  2. nucleoside biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciSENT882884:GJ8H-872-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC:2.4.2.21)
Short name:
NN:DBI PRT
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene namesi
Name:cobT
Ordered Locus Names:SARI_00872
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002084: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation
PRO_1000078247Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi41514.SARI_00872.

Structurei

3D structure databases

ProteinModelPortaliA9MLS8.
SMRiA9MLS8. Positions 3-349.

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.

Phylogenomic databases

eggNOGiCOG2038.
HOGENOMiHOG000263499.
OMAiAICSVIT.
OrthoDBiEOG6HF61K.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

A9MLS8-1 [UniParc]FASTAAdd to Basket

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MQTLHALLRD IPAPDTDAMA RAQQHIDGLL KPPGSLGRLE ALAVQLAGMP    50
GLNGTPQVGE KAMLVMCADH GVWDEGVAVS PKIVTAIQAA NMTRGTTGVC 100
VLAAQAGAKV HVIDVGIDAE PIPGVVNMRV ARGCGNIAVG PAMSRSQAEV 150
LLLEVIRYTC DLAQRGVTLF GVGELGMANT TPAAAMVSVF TGSDAKEVVG 200
IGANLPPSRI DNKVDVVRRA IAINQPDPHD GIDVLSKVGG FDLVGMTGVM 250
LGAARCGLPV LLDGFLSYSA ALAACQIAPA VRSYLIPSHF SAEKGARIAL 300
AHLAMEPYLH MAMRLGEGSG AALAMPIVEA ACAMFHNMGE LAASNIVLPG 350
EKQT 354
Length:354
Mass (Da):36,501
Last modified:February 5, 2008 - v1
Checksum:i1BD7DDC058C5CA6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000880 Genomic DNA. Translation: ABX20791.1.

Genome annotation databases

EnsemblBacteriaiABX20791; ABX20791; SARI_00872.
PATRICi18470900. VBISalEnt13497_0839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000880 Genomic DNA. Translation: ABX20791.1 .

3D structure databases

ProteinModelPortali A9MLS8.
SMRi A9MLS8. Positions 3-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41514.SARI_00872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX20791 ; ABX20791 ; SARI_00872 .
PATRICi 18470900. VBISalEnt13497_0839.

Phylogenomic databases

eggNOGi COG2038.
HOGENOMi HOG000263499.
OMAi AICSVIT.
OrthoDBi EOG6HF61K.

Enzyme and pathway databases

UniPathwayi UPA00061 ; UER00516 .
BioCyci SENT882884:GJ8H-872-MONOMER.

Family and domain databases

Gene3Di 1.10.1610.10. 1 hit.
HAMAPi MF_00230. CobT.
InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view ]
Pfami PF02277. DBI_PRT. 1 hit.
[Graphical view ]
SUPFAMi SSF52733. SSF52733. 1 hit.
TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Entry informationi

Entry nameiCOBT_SALAR
AccessioniPrimary (citable) accession number: A9MLS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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