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A9MLS8 (COBT_SALAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Short name=NN:DBI PRT
EC=2.4.2.21
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene names
Name:cobT
Ordered Locus Names:SARI_00872
OrganismSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP]
Taxonomic identifier41514 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity. HAMAP-Rule MF_00230

Catalytic activity

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate. HAMAP-Rule MF_00230

Pathway

Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. HAMAP-Rule MF_00230

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00230

Sequence similarities

Belongs to the CobT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase HAMAP-Rule MF_00230
PRO_1000078247

Sites

Active site3171Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A9MLS8 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 1BD7DDC058C5CA6D

FASTA35436,501
        10         20         30         40         50         60 
MQTLHALLRD IPAPDTDAMA RAQQHIDGLL KPPGSLGRLE ALAVQLAGMP GLNGTPQVGE 

        70         80         90        100        110        120 
KAMLVMCADH GVWDEGVAVS PKIVTAIQAA NMTRGTTGVC VLAAQAGAKV HVIDVGIDAE 

       130        140        150        160        170        180 
PIPGVVNMRV ARGCGNIAVG PAMSRSQAEV LLLEVIRYTC DLAQRGVTLF GVGELGMANT 

       190        200        210        220        230        240 
TPAAAMVSVF TGSDAKEVVG IGANLPPSRI DNKVDVVRRA IAINQPDPHD GIDVLSKVGG 

       250        260        270        280        290        300 
FDLVGMTGVM LGAARCGLPV LLDGFLSYSA ALAACQIAPA VRSYLIPSHF SAEKGARIAL 

       310        320        330        340        350 
AHLAMEPYLH MAMRLGEGSG AALAMPIVEA ACAMFHNMGE LAASNIVLPG EKQT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000880 Genomic DNA. Translation: ABX20791.1.

3D structure databases

ProteinModelPortalA9MLS8.
SMRA9MLS8. Positions 3-349.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING41514.SARI_00872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX20791; ABX20791; SARI_00872.
PATRIC18470900. VBISalEnt13497_0839.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2038.
HOGENOMHOG000263499.
OMAAICSVIT.
OrthoDBEOG6HF61K.

Enzyme and pathway databases

BioCycSENT882884:GJ8H-872-MONOMER.
UniPathwayUPA00061; UER00516.

Family and domain databases

Gene3D1.10.1610.10. 1 hit.
HAMAPMF_00230. CobT.
InterProIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMSSF52733. SSF52733. 1 hit.
TIGRFAMsTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOBT_SALAR
AccessionPrimary (citable) accession number: A9MLS8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways