A9MLK7 (TREF_SALAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytoplasmic trehalase
EC=3.2.1.28

Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase

Gene names

Name:	treF
Ordered Locus Names:	SARI_04033

Organism

Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP]

Taxonomic identifier

41514 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity By similarity. HAMAP MF_01059
Catalytic activity	Alpha,alpha-trehalose + H2O = 2 D-glucose. HAMAP MF_01059
Pathway	Glycan degradation; trehalose degradation; D-glucose from alpha,alpha-trehalose: step 1/1. HAMAP MF_01059
Subunit structure	Monomer By similarity. HAMAP MF_01059
Subcellular location	Cytoplasm By similarity HAMAP MF_01059.
Sequence similarities	Belongs to the glycosyl hydrolase 37 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular hyperosmotic response Inferred from electronic annotation. Source: InterPro trehalose catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alpha,alpha-trehalase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Cytoplasmic trehalase HAMAP MF_01059		PRO_1000084458

Sequences

	Sequence		Length	Mass (Da)
	A9MLK7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: BCD85669B36FB187	FASTA	549	63,614
	10 20 30 40 50 60 MLHQKLNPTS SEDLTIDVDL LYETDPCELK LDEMIEAEPE PEMIEGLPAS DALTPADRYL 70 80 90 100 110 120 ELFEHVQSTK LFPDSKTFPD CAPKMDPLDI LIRYRKVRRH RDFDLRRFVE NHFWLPETLS 130 140 150 160 170 180 SEYVSNPENS LKEHIDQLWP ILTREPQDHI PWSSLLALPQ SYIVPGGRFS ETYYWDSYFT 190 200 210 220 230 240 MLGLAESGRE DLLKCMADNF AWMIENYGHI PNGNRTYYLS RSQPPVFALM VELFEEDGVR 250 260 270 280 290 300 GARRYLDHLK MEYAFWMDGA ESLALNQAYR HVVRMPDGSL LNRYWDDRDT PRDESWLEDV 310 320 330 340 350 360 ETAKHSGRPP NEVYRDLRAG AASGWDYSSR WLRDAGRLAS IRTTQFIPID LNAFLYKLES 370 380 390 400 410 420 AIANISALKG ERDTEALFRQ KASDRRAAVN HYLWDDENGC YRDYDWRREE MALFSAASIV 430 440 450 460 470 480 PLYVGMANHE QADRLANVVR SRLLTPGGIM ATEYETGEQW DKPNGWAPLQ WMAIQGFKLY 490 500 510 520 530 540 GDDMLGDEIA HNWLKTVNHF YQEHHKLIEK YHISGGTPRE GGGGEYPLQD GFGWTNGVVR RLIGLYGEP

References

[1]

The Salmonella enterica serovar Arizonae Genome Sequencing Project McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000880 Genomic DNA. Translation: ABX23826.1.
RefSeq	YP_001572968.1. NC_010067.1.
3D structure databases
ProteinModelPortal	A9MLK7.
ModBase	Search...
Protein-protein interaction databases
STRING	A9MLK7.
Protein family/group databases
CAZy	GH37. Glycoside Hydrolase Family 37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5761249.
GenomeReviews	Gene locus SARI_04033 in contig CP000880_GR.
KEGG	ses:SARI_04033.
PATRIC	18477025. VBISalEnt13497_3823.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG485982.
OMA	FWMDGAD.
ProtClustDB	PRK13270.
Family and domain databases
HAMAP	MF_01059. Cyt_trehalase. [Tree]
InterPro	IPR008928. 6-hairpin_glycosidase-like. IPR023715. Cyt_trehalase. IPR001661. Glyco_hydro_37. IPR018232. Glyco_hydro_37_CS. [Graphical view]
KO	K01194.
PANTHER	PTHR23403. Glyco_hydro_37. 1 hit.
Pfam	PF01204. Trehalase. 1 hit. [Graphical view]
PRINTS	PR00744. GLHYDRLASE37.
SUPFAM	SSF48208. Glyco_trans_6hp. 1 hit.
PROSITE	PS00927. TREHALASE_1. 1 hit. PS00928. TREHALASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TREF_SALAR

Accession

Primary (citable) accession number: A9MLK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program