Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

SARI_00803

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SARI_00803)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102NADPUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Active sitei183Proton acceptorUniRule annotation1
Active sitei190Proton donorUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Binding sitei260Substrate; via amide nitrogenUniRule annotation1
Binding sitei287SubstrateUniRule annotation1
Binding sitei445Substrate; shared with dimeric partnerUniRule annotation1
Binding sitei451Substrate; shared with dimeric partnerUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADPUniRule annotation6
Nucleotide bindingi33 – 35NADPUniRule annotation3
Nucleotide bindingi74 – 76NADPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGluconate utilizationUniRule annotation, Pentose shuntUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Ordered Locus Names:SARI_00803Imported
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)Imported
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi882884.SARI_00803

Structurei

3D structure databases

ProteinModelPortaliA9ML07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 4676PGDInterPro annotationAdd BLAST289

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 130Substrate bindingUniRule annotation3
Regioni186 – 187Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7Q Bacteria
COG0362 LUCA
HOGENOMiHOG000255147
KOiK00033
OMAiNSHYPDS
OrthoDBiPOG091H01QF

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

A9ML07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK
60 70 80 90 100
LVPYYTVKEF VESLETPRRI LLMVKAGAGT DATIDSLKPY LEKGDIIIDG
110 120 130 140 150
GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKDAYE
160 170 180 190 200
LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA
210 220 230 240 250
YSLLKGGLNL SNEELASTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV
260 270 280 290 300
DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS
310 320 330 340 350
KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASEEYHWD
360 370 380 390 400
LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NAGIANLLLA PYFRKIADEY
410 420 430 440 450
QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA
460
HTYKRTDKDG IFHTEWLE
Length:468
Mass (Da):51,368
Last modified:February 5, 2008 - v1
Checksum:i812E7DD5F8B1E780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA Translation: ABX20723.1
RefSeqiWP_000043538.1, NC_010067.1

Genome annotation databases

EnsemblBacteriaiABX20723; ABX20723; SARI_00803
KEGGises:SARI_00803

Entry informationi

Entry nameiA9ML07_SALAR
AccessioniPrimary (citable) accession number: A9ML07
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health