Skip Header

Contribute Send feedback
Read comments (?) or add your own

A9ML07 (A9ML07_SALAR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:SARI_00803
OrganismSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP] EMBL ABX20723.1
Taxonomic identifier41514 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU000485

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding74 – 763NADP By similarity PIRSR PIRSR000109-3
Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region186 – 1872Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1831Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1901Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021NADP By similarity PIRSR PIRSR000109-3
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1911Substrate By similarity PIRSR PIRSR000109-2
Binding site2601Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2871Substrate By similarity PIRSR PIRSR000109-2
Binding site4451Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4511Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A9ML07 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 812E7DD5F8B1E780

FASTA46851,368
        10         20         30         40         50         60 
MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK LVPYYTVKEF 

        70         80         90        100        110        120 
VESLETPRRI LLMVKAGAGT DATIDSLKPY LEKGDIIIDG GNTFFQDTIR RNRELSAEGF 

       130        140        150        160        170        180 
NFIGTGVSGG EEGALKGPSI MPGGQKDAYE LVAPILTKIA AVAEDGEPCV TYIGADGAGH 

       190        200        210        220        230        240 
YVKMVHNGIE YGDMQLIAEA YSLLKGGLNL SNEELASTFT EWNNGELSSY LIDITKDIFT 

       250        260        270        280        290        300 
KKDEDGNYLV DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS 

       310        320        330        340        350        360 
KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASEEYHWD LNYGEIAKIF 

       370        380        390        400        410        420 
RAGCIIRAQF LQKITDAYAE NAGIANLLLA PYFRKIADEY QQALRDVVAY AVQNGIPVPT 

       430        440        450        460 
FSAAVAYYDS YRAAVLPANL IQAQRDYFGA HTYKRTDKDG IFHTEWLE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000880 Genomic DNA. Translation: ABX20723.1.
RefSeqYP_001569865.1. NC_010067.1.

3D structure databases

ProteinModelPortalA9ML07.
SMRA9ML07. Positions 1-466.
ModBaseSearch...

Protein-protein interaction databases

STRING41514.SARI_00803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX20723; ABX20723; SARI_00803.
GeneID5764449.
KEGGses:SARI_00803.
PATRIC18470762. VBISalEnt13497_0770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHOG000255147.
KOK00033.
OMAKQQIGVI.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycSENT882884:GJ8H-803-MONOMER.
UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9ML07_SALAR
AccessionPrimary (citable) accession number: A9ML07
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info