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A9ML07

- A9ML07_SALAR

UniProt

A9ML07 - A9ML07_SALAR

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

SARI_00803

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021NADPUniRule annotation
    Binding sitei102 – 1021SubstrateUniRule annotation
    Active sitei183 – 1831Proton acceptorUniRule annotation
    Active sitei190 – 1901Proton donorUniRule annotation
    Binding sitei191 – 1911SubstrateUniRule annotation
    Binding sitei260 – 2601Substrate; via amide nitrogenUniRule annotation
    Binding sitei287 – 2871SubstrateUniRule annotation
    Binding sitei445 – 4451Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei451 – 4511Substrate; shared with dimeric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADP
    Nucleotide bindingi33 – 353NADP
    Nucleotide bindingi74 – 763NADP

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSENT882884:GJ8H-803-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
    Gene namesi
    Ordered Locus Names:SARI_00803Imported
    OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)Imported
    Taxonomic identifieri41514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002084: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi41514.SARI_00803.

    Structurei

    3D structure databases

    ProteinModelPortaliA9ML07.
    SMRiA9ML07. Positions 1-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1303Substrate bindingUniRule annotation
    Regioni186 – 1872Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9ML07-1 [UniParc]FASTAAdd to Basket

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    MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK    50
    LVPYYTVKEF VESLETPRRI LLMVKAGAGT DATIDSLKPY LEKGDIIIDG 100
    GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKDAYE 150
    LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA 200
    YSLLKGGLNL SNEELASTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV 250
    DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS 300
    KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASEEYHWD 350
    LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NAGIANLLLA PYFRKIADEY 400
    QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA 450
    HTYKRTDKDG IFHTEWLE 468
    Length:468
    Mass (Da):51,368
    Last modified:February 5, 2008 - v1
    Checksum:i812E7DD5F8B1E780
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX20723.1.

    Genome annotation databases

    EnsemblBacteriaiABX20723; ABX20723; SARI_00803.
    PATRICi18470762. VBISalEnt13497_0770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX20723.1 .

    3D structure databases

    ProteinModelPortali A9ML07.
    SMRi A9ML07. Positions 1-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41514.SARI_00803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX20723 ; ABX20723 ; SARI_00803 .
    PATRICi 18470762. VBISalEnt13497_0770.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci SENT882884:GJ8H-803-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-731 / CDC346-86 / RSK2980Imported.

    Entry informationi

    Entry nameiA9ML07_SALAR
    AccessioniPrimary (citable) accession number: A9ML07
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3