Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A9MJ30 (GPPA_SALAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:SARI_03739
OrganismSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP]
Taxonomic identifier41514 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000087731

Sequences

Sequence LengthMass (Da)Tools
A9MJ30 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 413F9A79100FB138

FASTA49454,910
        10         20         30         40         50         60 
MLNSTSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLSSDN QLSAEAMERG 

        70         80         90        100        110        120 
WQCLRLFAER LQDIPQPQIR VVATATLRLA VNAGEFIAKA QTILGCPVQV ISGEEEARLI 

       130        140        150        160        170        180 
YQGVAHTTGG AEQRLVVDIG GASTELVTGT GAQTTSLFSL SMGCVTWLEH YFSDRNLAQE 

       190        200        210        220        230        240 
NFDDAEKAAR DVLRPVADKL RFHGWKVCVG ASGTVQALQE IMMAQGMDER ITLAKLQQLK 

       250        260        270        280        290        300 
QRAIQCGRLE ELEIEGLTLE RALVFPSGLA ILIAIFTELN IQFMTLAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLTVDQDICS RTLRNIQRRF IIDTDQANRV AKLAGNFLKQ VENAWHIEPI SRELLLSACQ 

       370        380        390        400        410        420 
LHEIGLSVDF KQAPYHAAYL VRHLDLPGYT PAQKKLLATL LLNQTNPVDL SSLHQQNAVP 

       430        440        450        460        470        480 
PRVAEQLCRL LRLAILFAGR RRDDLVPEIT LQAQNENLTL TLPDGWLAHH PLGKELIDQE 

       490 
SQWQSYVHWP LDIR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000880 Genomic DNA. Translation: ABX23539.1.

3D structure databases

ProteinModelPortalA9MJ30.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING41514.SARI_03739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX23539; ABX23539; SARI_03739.
PATRIC18476453. VBISalEnt13497_3545.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycSENT882884:GJ8H-3733-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_SALAR
AccessionPrimary (citable) accession number: A9MJ30
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways