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A9MJ30

- GPPA_SALAR

UniProt

A9MJ30 - GPPA_SALAR

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSENT882884:GJ8H-3733-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:SARI_03739
    OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
    Taxonomic identifieri41514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002084: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000087731Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi41514.SARI_03739.

    Structurei

    3D structure databases

    ProteinModelPortaliA9MJ30.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9MJ30-1 [UniParc]FASTAAdd to Basket

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    MLNSTSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLSSDN    50
    QLSAEAMERG WQCLRLFAER LQDIPQPQIR VVATATLRLA VNAGEFIAKA 100
    QTILGCPVQV ISGEEEARLI YQGVAHTTGG AEQRLVVDIG GASTELVTGT 150
    GAQTTSLFSL SMGCVTWLEH YFSDRNLAQE NFDDAEKAAR DVLRPVADKL 200
    RFHGWKVCVG ASGTVQALQE IMMAQGMDER ITLAKLQQLK QRAIQCGRLE 250
    ELEIEGLTLE RALVFPSGLA ILIAIFTELN IQFMTLAGGA LREGLVYGML 300
    HLTVDQDICS RTLRNIQRRF IIDTDQANRV AKLAGNFLKQ VENAWHIEPI 350
    SRELLLSACQ LHEIGLSVDF KQAPYHAAYL VRHLDLPGYT PAQKKLLATL 400
    LLNQTNPVDL SSLHQQNAVP PRVAEQLCRL LRLAILFAGR RRDDLVPEIT 450
    LQAQNENLTL TLPDGWLAHH PLGKELIDQE SQWQSYVHWP LDIR 494
    Length:494
    Mass (Da):54,910
    Last modified:February 5, 2008 - v1
    Checksum:i413F9A79100FB138
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX23539.1.

    Genome annotation databases

    EnsemblBacteriaiABX23539; ABX23539; SARI_03739.
    PATRICi18476453. VBISalEnt13497_3545.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX23539.1 .

    3D structure databases

    ProteinModelPortali A9MJ30.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41514.SARI_03739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX23539 ; ABX23539 ; SARI_03739 .
    PATRICi 18476453. VBISalEnt13497_3545.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci SENT882884:GJ8H-3733-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

    Entry informationi

    Entry nameiGPPA_SALAR
    AccessioniPrimary (citable) accession number: A9MJ30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3