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A9MHU8

- PNCB_SALAR

UniProt

A9MHU8 - PNCB_SALAR

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSENT882884:GJ8H-1954-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:SARI_01957
    OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
    Taxonomic identifieri41514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002084: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Nicotinate phosphoribosyltransferasePRO_1000082327Add
    BLAST

    Proteomic databases

    PRIDEiA9MHU8.

    Interactioni

    Protein-protein interaction databases

    STRINGi41514.SARI_01957.

    Structurei

    3D structure databases

    ProteinModelPortaliA9MHU8.
    SMRiA9MHU8. Positions 2-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9MHU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY    50
    ADAIREQVDA MQHLRLQEDE FQWLSGLPFF KTDYLDWLRE FRYDPAQVCV 100
    TNDNGKLNIR LTGPWREVIM WEVPLLAVIS ELVHHYRSPK AGVDQALDAL 150
    ESKLVDFTAL TADLDMSRFH LMDFGTRRRF SREVQQTIVK RLQQEPWFVG 200
    TSNYDLARRL ALMPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLNEYPD 250
    QLGIALTDCI TMDAFLRDFG VEFASHYQGL RHDSGDPVEW GEKAIAHYEK 300
    LGIDPMTKTL VFSDNLDLQK AVELYRHFAS RVQLSFGIGT RLTCDIPQVK 350
    PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQVRKAS 400
    Length:400
    Mass (Da):45,841
    Last modified:February 5, 2008 - v1
    Checksum:i088098AB83FE4CAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX21838.1.

    Genome annotation databases

    EnsemblBacteriaiABX21838; ABX21838; SARI_01957.
    PATRICi18473018. VBISalEnt13497_1880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX21838.1 .

    3D structure databases

    ProteinModelPortali A9MHU8.
    SMRi A9MHU8. Positions 2-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41514.SARI_01957.

    Proteomic databases

    PRIDEi A9MHU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX21838 ; ABX21838 ; SARI_01957 .
    PATRICi 18473018. VBISalEnt13497_1880.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci SENT882884:GJ8H-1954-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

    Entry informationi

    Entry nameiPNCB_SALAR
    AccessioniPrimary (citable) accession number: A9MHU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3