A9MH27 (GHRA_SALAR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 29.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glyoxylate/hydroxypyruvate reductase A EC=1.1.1.79 EC=1.1.1.81 Alternative name(s): 2-ketoacid reductase | ||||
| Gene names |
| ||||
| Organism | Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 41514 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 312 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively By similarity. HAMAP MF_01666 |
| Catalytic activity | Glycolate + NADP+ = glyoxylate + NADPH. HAMAP MF_01666 D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. HAMAP MF_01666 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_01666. |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | cofactor binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase (NADP) activityInferred from electronic annotation. Source: EC hydroxypyruvate reductase activityInferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 312 | 312 | Glyoxylate/hydroxypyruvate reductase A HAMAP MF_01666 | PRO_0000348367 | |||||
Sites | |||||||||
| Active site | 227 | 1 | By similarity | ||||||
| Active site | 275 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| [1] | The Salmonella enterica serovar Arizonae Genome Sequencing Project McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-731 / CDC346-86 / RSK2980. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000880 Genomic DNA. Translation: ABX21747.1. |
| RefSeq | YP_001570888.1. NC_010067.1. |
3D structure databases | |
| ProteinModelPortal | A9MH27. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A9MH27. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5761154. |
| GenomeReviews | Gene locus SARI_01863 in contig CP000880_GR. |
| KEGG | ses:SARI_01863. |
| PATRIC | 18472826. VBISalEnt13497_1786. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG731446. |
| OMA | EYVTHAV. |
| ProtClustDB | PRK15469. |
Family and domain databases | |
| HAMAP | MF_01666. 2-Hacid_dh_C_GhrA. [Tree] |
| InterPro | IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR023514. GhrA. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K12972. |
| Pfam | PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. False negative. PS00670. D_2_HYDROXYACID_DH_2. False negative. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GHRA_SALAR | ||||||||
| Accession | Primary (citable) accession number: A9MH27 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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