A9MFX7 (NORR_SALAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anaerobic nitric oxide reductase transcription regulator NorR

Gene names

Name:	norR
Ordered Locus Names:	SARI_00132

Organism

Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP]

Taxonomic identifier

41514 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica subsp. arizonae

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 By similarity. HAMAP-Rule MF_01314
Pathway	Nitrogen metabolism; nitric oxide reduction. HAMAP-Rule MF_01314
Sequence similarities	Contains 1 sigma-54 factor interaction domain.
Sequence caution	The sequence ABX20085.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	ATP-binding DNA-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphorelay signal transduction system Inferred from electronic annotation. Source: HAMAP sensory perception Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Anaerobic nitric oxide reductase transcription regulator NorR HAMAP-Rule MF_01314		PRO_0000341321
Regions
	Domain	187 – 416	230	Sigma-54 factor interaction
	Nucleotide binding	215 – 222	8	ATP Potential
	Nucleotide binding	278 – 287	10	ATP Potential
	DNA binding	481 – 500	20	H-T-H motif By similarity
Amino acid modifications
	Modified residue	57	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9MFX7 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: 2A70283EE3E72A19	FASTA	506	55,398
	10 20 30 40 50 60 MSFSVEVLAG IAIELQRGIG HQDRFQRLIT TLRQVLACDA SALLRYESGQ FIPLAIDGLA 70 80 90 100 110 120 QDVLGRRFTL EGHPRLEAIA RAGDVVRFPA DSDLPDPYDG LIPGQESLKV HACVGLPLFA 130 140 150 160 170 180 GQNLIGALTF DAMTPAQFEV FSDEELRLIA ALAAGALSNA LLIEQLESQN MLPRSSAAFE 190 200 210 220 230 240 PIKETHMIGL SPAMTQLKKE IEIVASSDLN VLIGGETGTG KELVAKAIHQ GSPRAVNPLV 250 260 270 280 290 300 YLNCAALPES VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL 310 320 330 340 350 360 RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV FPLFVPPLRE 370 380 390 400 410 420 RGNDVVLLAG YFCEQCRLRL GLSRVVLSPG ARRHLLNYGW PGNVRELEHA IHRAVVLARA 430 440 450 460 470 480 TRAGDEVILE AQHFALSEDV LPAPPAESFL ALPNCRNLRE STENFQRELI RQALAQNHHN 490 500 WAASARALET DVANLHRLAK RLGLKD

References

[1]

The Salmonella enterica serovar Arizonae Genome Sequencing Project McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000880 Genomic DNA. Translation: ABX20085.1. Different initiation.
3D structure databases
ProteinModelPortal	A9MFX7.
ModBase	Search...
Protein-protein interaction databases
STRING	41514.SARI_00132.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX20085; ABX20085; SARI_00132.
PATRIC	18469447. VBISalEnt13497_0131.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3604.
HOGENOM	HOG000058487.
ProtClustDB	PRK05022.
Enzyme and pathway databases
UniPathway	UPA00638.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
HAMAP	MF_01314. NorR.
InterPro	IPR003593. AAA+_ATPase. IPR003018. GAF. IPR009057. Homeodomain-like. IPR023944. NorR. IPR002078. Sigma_54_int. IPR025662. Sigma_54_int_dom_ATP-bd_1. IPR025943. Sigma_54_int_dom_ATP-bd_2. IPR025944. Sigma_54_int_dom_CS. [Graphical view]
Pfam	PF01590. GAF. 1 hit. PF00158. Sigma54_activat. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00065. GAF. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00675. SIGMA54_INTERACT_1. 1 hit. PS00676. SIGMA54_INTERACT_2. 1 hit. PS00688. SIGMA54_INTERACT_3. 1 hit. PS50045. SIGMA54_INTERACT_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NORR_SALAR

Accession

Primary (citable) accession number: A9MFX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program