A9MFG0 (ASTD_SALAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71

Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	SARI_01674

Organism

Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) [Complete proteome] [HAMAP]

Taxonomic identifier

41514 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000085404
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9MFG0 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 98C7F8A8930D5A00	FASTA	492	53,001
	10 20 30 40 50 60 MTLWINGDWI TGQGERRSKT NPVSAEILWQ GNDADTAQVA GACEAARAAF PCWARQPFAA 70 80 90 100 110 120 RQAIVEKFAV LLEEHKAELT AVIARETGKP RWEAATEVTA MINKIAISIK AYHARTGEQT 130 140 150 160 170 180 SELADGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLIFKPS ELTPWTGETV 190 200 210 220 230 240 IKLWERAGLP AGVLNLVQGG RETGHALSLL DDLDGLLFTG SASTGYQLHR QLSGQPKKIL 250 260 270 280 290 300 ALEMGGNNPL IIEDAEDIDA AVHLTLQSAF ITAGQRCTCA RRLLVKQGVQ GDAFLARLVD 310 320 330 340 350 360 VAGRLQPGRW DDDPQPFIGG LISAQAAQHV IEAWHQREAL GGRTLLAPRK VKEGTSLLTP 370 380 390 400 410 420 GIIELTGVTD VPDEEVFGPL LSVWRYDHFD EAIHLANSTR FGLSCGLVST DRAQFEQLLL 430 440 450 460 470 480 EARAGIVNWN KPLTGAASTS PFGGVGASGN HRPSAWYAAD YCAWPMATLE SPELTLPATL 490 SPGLDFSRRE AV

References

[1]

The Salmonella enterica serovar Arizonae Genome Sequencing Project McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000880 Genomic DNA. Translation: ABX21565.1.
RefSeq	YP_001570707.1. NC_010067.1.
3D structure databases
ProteinModelPortal	A9MFG0.
ModBase	Search...
Protein-protein interaction databases
STRING	A9MFG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5763416.
GenomeReviews	Gene locus SARI_01674 in contig CP000880_GR.
KEGG	ses:SARI_01674.
PATRIC	18472441. VBISalEnt13497_1596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG752218.
OMA	KAYHART.
ProtClustDB	PRK09457.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K06447.
PANTHER	PTHR11699:SF24. PTHR11699:SF24. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. Arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SALAR

Accession

Primary (citable) accession number: A9MFG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program