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A9MF31

- SURE_SALAR

UniProt

A9MF31 - SURE_SALAR

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Protein
5'/3'-nucleotidase SurE
Gene
surE, SARI_00029
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs By similarity.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Divalent metal cation By similarity
Metal bindingi9 – 91Divalent metal cation By similarity
Metal bindingi39 – 391Divalent metal cation By similarity
Metal bindingi92 – 921Divalent metal cation By similarity

GO - Molecular functioni

  1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
  2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
  3. exopolyphosphatase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-HAMAP
  5. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT882884:GJ8H-29-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'/3'-nucleotidase SurE (EC:3.1.3.5, EC:3.1.3.6)
    Alternative name(s):
    Exopolyphosphatase (EC:3.6.1.11)
    Nucleoside monophosphate phosphohydrolase
    Gene namesi
    Name:surE
    Ordered Locus Names:SARI_00029
    OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
    Taxonomic identifieri41514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002084: Chromosome

    Subcellular locationi

    Cytoplasm Reviewed prediction UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532535'/3'-nucleotidase SurEUniRule annotation
    PRO_1000075038Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi41514.SARI_00029.

    Structurei

    3D structure databases

    ProteinModelPortaliA9MF31.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.

    Phylogenomic databases

    eggNOGiCOG0496.
    HOGENOMiHOG000122500.
    OMAiIPSMALS.
    OrthoDBiEOG68WR45.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    HAMAPiMF_00060. SurE.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9MF31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILLSNDDG IHAPGIQTLA KALREFADVQ VVAPDRNRSG ASNSLTLESS    50
    LRTFTFDNGD IAVQMGTPTD CVYLGVNALM RPRPDIVVSG INAGPNLGDD 100
    VIYSGTVAAA MEGRHLGFPA LAVSLNGYQH YDTAAAVTCA LLRGLSREPL 150
    RTGRILNVNV PDLPLAQIKG IRVTRCGSRH PADKVIPQED PRGNTLYWIG 200
    PPGDKYDAGP DTDFAAVDEG YVSVTPLHVD LTAHSAHDVV SDWLDSVGVG 250
    TQW 253
    Length:253
    Mass (Da):27,008
    Last modified:February 5, 2008 - v1
    Checksum:iE92BC60D95F21C29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX19983.1.

    Genome annotation databases

    EnsemblBacteriaiABX19983; ABX19983; SARI_00029.
    PATRICi18469243. VBISalEnt13497_0029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000880 Genomic DNA. Translation: ABX19983.1 .

    3D structure databases

    ProteinModelPortali A9MF31.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 41514.SARI_00029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX19983 ; ABX19983 ; SARI_00029 .
    PATRICi 18469243. VBISalEnt13497_0029.

    Phylogenomic databases

    eggNOGi COG0496.
    HOGENOMi HOG000122500.
    OMAi IPSMALS.
    OrthoDBi EOG68WR45.

    Enzyme and pathway databases

    BioCyci SENT882884:GJ8H-29-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    HAMAPi MF_00060. SurE.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

    Entry informationi

    Entry nameiSURE_SALAR
    AccessioniPrimary (citable) accession number: A9MF31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: May 14, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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