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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 271SubstrateUniRule annotation
Active sitei80 – 801NucleophileUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Binding sitei329 – 3291SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciSENT882884:GJ8H-28-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:SARI_00028
OrganismiSalmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Taxonomic identifieri41514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002084 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349tRNA pseudouridine synthase DPRO_1000084763Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi882884.SARI_00028.

Structurei

3D structure databases

ProteinModelPortaliA9MF30.
SMRiA9MF30. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 303149TRUDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation
Contains 1 TRUD domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV. Bacteria.
COG0585. LUCA.
HOGENOMiHOG000224848.
KOiK06176.
OMAiLWLWVEK.
OrthoDBiEOG6FRCSP.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9MF30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFENLTWL HGKPQGSGLL KANPEDFVVV EDLGFTPDGE GEHILVRILK
60 70 80 90 100
NGCNTRFVAD ALAKFLKIHA REVSFAGQKD KHAVTEQWLC ARVPGKEMPD
110 120 130 140 150
FSAFQLEGCK VLEYARHKRK LRLGALKGNA FTLVLREISD RRDVETRLQA
160 170 180 190 200
IRDSGVPNYF GAQRFGIGGS NLQGALRWAQ SDAPVRDRNK RSFWLSAARS
210 220 230 240 250
ALFNQIVSQR LKKTDFNQVV DGDTLQLAGR GSWFVATSEE LPELQRRVDE
260 270 280 290 300
KELMITASLP GRGEWGTQRD ALAFEQDAIA QETVLQSLLL REKVEASRRA
310 320 330 340
MLLYPQQLSW NWWDDVTVEL RFWLPAGSFA TSVVRELINT IGDYAHIAE
Length:349
Mass (Da):39,443
Last modified:February 5, 2008 - v1
Checksum:iC46D772B52CDA270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA. Translation: ABX19982.1.
RefSeqiWP_000134261.1. NC_010067.1.

Genome annotation databases

EnsemblBacteriaiABX19982; ABX19982; SARI_00028.
KEGGises:SARI_00028.
PATRICi18469241. VBISalEnt13497_0028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000880 Genomic DNA. Translation: ABX19982.1.
RefSeqiWP_000134261.1. NC_010067.1.

3D structure databases

ProteinModelPortaliA9MF30.
SMRiA9MF30. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882884.SARI_00028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX19982; ABX19982; SARI_00028.
KEGGises:SARI_00028.
PATRICi18469241. VBISalEnt13497_0028.

Phylogenomic databases

eggNOGiENOG4106NZV. Bacteria.
COG0585. LUCA.
HOGENOMiHOG000224848.
KOiK06176.
OMAiLWLWVEK.
OrthoDBiEOG6FRCSP.

Enzyme and pathway databases

BioCyciSENT882884:GJ8H-28-MONOMER.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-731 / CDC346-86 / RSK2980.

Entry informationi

Entry nameiTRUD_SALAR
AccessioniPrimary (citable) accession number: A9MF30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 11, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.