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A9ME88

- GLSA_BRUC2

UniProt

A9ME88 - GLSA_BRUC2

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Protein
Glutaminase
Gene
glsA, BCAN_B0342
Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei263 – 2631Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBCAN483179:GJ7I-2545-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:BCAN_B0342
OrganismiBrucella canis (strain ATCC 23365 / NCTC 10854)
Taxonomic identifieri483179 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001385: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317GlutaminaseUniRule annotation
PRO_1000079071Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi483179.BCAN_B0342.

Structurei

3D structure databases

ProteinModelPortaliA9ME88.
SMRiA9ME88. Positions 5-309.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiSLANERN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9ME88-1 [UniParc]FASTAAdd to Basket

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MSSSSDAIKA ALEKGRAAGL SATGGKNADY IPFLASVPSD LFGLAVVTAD    50
GQTFKTGDAD FAFAIESISK VFTLALVMEE IGPDSVREKV GADPTGLPFN 100
SVIALELHNG KSLSPLVNAG AIATASLVPG DTADARWNNI LECQCGFAGR 150
RLKLSNEVNQ SEQTTNFHNR AIAWLLYSAG TCYSDPMEAV DIYTRQCSTL 200
VTATDLATMG ATLAAGGVNP ISGKRMVSAG NVAPILAEMT MEGLYTASGD 250
WAYTVGLPGK SGVGGGIMAV VPGELAIAAF SPPLDPAGNS VKAMAAVAAV 300
ADSLGHNLYT TRGKVSS 317
Length:317
Mass (Da):32,443
Last modified:February 5, 2008 - v1
Checksum:iA7B2A39A9A7EB02D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000873 Genomic DNA. Translation: ABX63526.1.
RefSeqiYP_001594297.1. NC_010104.1.

Genome annotation databases

EnsemblBacteriaiABX63526; ABX63526; BCAN_B0342.
GeneIDi5786377.
KEGGibcs:BCAN_B0342.
PATRICi17833881. VBIBruCan25663_2563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000873 Genomic DNA. Translation: ABX63526.1 .
RefSeqi YP_001594297.1. NC_010104.1.

3D structure databases

ProteinModelPortali A9ME88.
SMRi A9ME88. Positions 5-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 483179.BCAN_B0342.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX63526 ; ABX63526 ; BCAN_B0342 .
GeneIDi 5786377.
KEGGi bcs:BCAN_B0342.
PATRICi 17833881. VBIBruCan25663_2563.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi SLANERN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci BCAN483179:GJ7I-2545-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23365 / NCTC 10854.

Entry informationi

Entry nameiGLSA_BRUC2
AccessioniPrimary (citable) accession number: A9ME88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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