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Protein

ATP phosphoribosyltransferase regulatory subunit

Gene

hisZ

Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.UniRule annotation

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Biological processi

Keywordsi

Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase regulatory subunitUniRule annotation
Gene namesi
Name:hisZUniRule annotation
Ordered Locus Names:BCAN_B0188
OrganismiBrucella canis (strain ATCC 23365 / NCTC 10854)
Taxonomic identifieri483179 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000001385 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000762421 – 376ATP phosphoribosyltransferase regulatory subunitAdd BLAST376

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000141880.
KOiK02502.
OMAiYYTGFEF.

Family and domain databases

HAMAPiMF_00125. HisZ. 1 hit.
InterProiView protein in InterPro
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
PANTHERiPTHR43707. PTHR43707. 1 hit.
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

A9MDU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGSRTSPIF NALRVELNAR EAELVEIPLI QPADPFLDMA GEDLRRRIFL
60 70 80 90 100
TENENGDSLC LRPEFTIPVC RNHIALNAAT PKRYAYLGEV FRQRRDGAAE
110 120 130 140 150
FLQAGIEDLG AADEAASDAR SLADALSCVK AIAPDAPLEI VLGDQSVFAG
160 170 180 190 200
MLKALGLPQG WRKKLLRSFG DAHSMDLALA ELTGTQRRDP LPESLAVLVA
210 220 230 240 250
EGDEIGLARM LEAEMLEAGI SPGAGRTPVE IARRLIEKED LAATHFPAAA
260 270 280 290 300
LDLLRQFLAI RVSLDTAAVT LRAFAADNAL DLGAVLQKFE ARADAIAQAG
310 320 330 340 350
IEMKDIIYDA SFGRPLDYYT GLVYEIRDAS NRQDGVLAGG GRYDRLLTML
360 370
GACEAIPGVG FSIWLDRLQA LAGEKQ
Length:376
Mass (Da):40,659
Last modified:February 5, 2008 - v1
Checksum:iC2B28FA6CF6D02CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000873 Genomic DNA. Translation: ABX63383.1.
RefSeqiWP_005971898.1. NC_010104.1.

Genome annotation databases

EnsemblBacteriaiABX63383; ABX63383; BCAN_B0188.
GeneIDi29595961.
KEGGibcs:BCAN_B0188.

Similar proteinsi

Entry informationi

Entry nameiHISZ_BRUC2
AccessioniPrimary (citable) accession number: A9MDU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: August 30, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families