Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBCAN483179:GJ7I-3284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:BCAN_B1091
OrganismiBrucella canis (strain ATCC 23365 / NCTC 10854)
Taxonomic identifieri483179 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000001385 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Peptide methionine sulfoxide reductase MsrAPRO_1000087345Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9MCZ5.
SMRiA9MCZ5. Positions 15-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263862.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9MCZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFDSYRKK MQMPSKEEVL PGRVQPIPTA AAHFVSGHPL KGPWPDGMKQ
60 70 80 90 100
VLFGMGCFWG AERLFWQVPG VYVTAVGYAG GITPNPTYEE TCTGLTGHAE
110 120 130 140 150
VVLVVYDPKV VTLNELLALF WEEHDPTQGM RQGNDIGTTY RSVIYTFNAV
160 170 180 190 200
DRAVAEKSRD AYSQALASRG LGPVTTQIAD APDFYYAEDY HQQYLAKNPD
210
GYCGLRGTGV SCPIPLAH
Length:218
Mass (Da):24,017
Last modified:February 5, 2008 - v1
Checksum:i64B43110667417B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000873 Genomic DNA. Translation: ABX64232.1.
RefSeqiWP_002965585.1. NC_010104.1.

Genome annotation databases

EnsemblBacteriaiABX64232; ABX64232; BCAN_B1091.
GeneIDi3827249.
KEGGibcs:BCAN_B1091.
PATRICi17835360. VBIBruCan25663_3293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000873 Genomic DNA. Translation: ABX64232.1.
RefSeqiWP_002965585.1. NC_010104.1.

3D structure databases

ProteinModelPortaliA9MCZ5.
SMRiA9MCZ5. Positions 15-213.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX64232; ABX64232; BCAN_B1091.
GeneIDi3827249.
KEGGibcs:BCAN_B1091.
PATRICi17835360. VBIBruCan25663_3293.

Phylogenomic databases

HOGENOMiHOG000263862.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiEOG6091JX.

Enzyme and pathway databases

BioCyciBCAN483179:GJ7I-3284-MONOMER.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23365 / NCTC 10854.

Entry informationi

Entry nameiMSRA_BRUC2
AccessioniPrimary (citable) accession number: A9MCZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: December 9, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.