ID   TRUA_BRUC2              Reviewed;         251 AA.
AC   A9MCV8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   16-JUN-2009, entry version 10.
DE   RecName: Full=tRNA pseudouridine synthase A;
DE            EC=5.4.99.12;
DE   AltName: Full=tRNA-uridine isomerase I;
DE   AltName: Full=tRNA pseudouridylate synthase I;
GN   Name=truA; OrderedLocusNames=BCAN_B1053;
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=483179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J.,
RA   Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S.,
RA   Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K.,
RA   Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W.,
RA   Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C.,
RA   Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC       the anticodon stem and loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase truA
CC       family.
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DR   EMBL; CP000873; ABX64195.1; -; Genomic_DNA.
DR   RefSeq; YP_001594966.1; -.
DR   GeneID; 5787297; -.
DR   GenomeReviews; CP000873_GR; BCAN_B1053.
DR   KEGG; bcs:BCAN_B1053; -.
DR   OMA; A9MCV8; NNDNTIQ.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR   HAMAP; MF_00171; -; 1.
DR   InterPro; IPR001406; tRNA_psdUrid_synth.
DR   Gene3D; G3DSA:3.30.70.580; PseudoU_synth_1; 1.
DR   Gene3D; G3DSA:3.30.70.660; PseudoU_synth_1; 1.
DR   PANTHER; PTHR11142; PseudoU_synth_1; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    251       tRNA pseudouridine synthase A.
FT                                /FTId=PRO_1000077082.
FT   ACT_SITE     52     52       Nucleophile (By similarity).
SQ   SEQUENCE   251 AA;  28172 MW;  E2A62312443C2BCD CRC64;
     MPRYKLTVEY DGTPYVGWQR QENGHAVQGA IEQAFKKFCG EDLTLSAAGR TDAGVHATAQ
     VAHVDLAKDW GAGKVRDAVN AHLVMADERI SILNVEKTTD TFDARFSARA RHYLYRIHNR
     RAPLAVDYQR AWWVQKQLDA DAMHEAAQRL LGEHDFTTFR ATQCQAKSPV KTLDRLDVTR
     NGDMVEMRVS ARSFLHNQVR SFAGSLMEVG VGRWTADDLQ AALEARDRKA CGQVAPPYGL
     YLVGVDYAFP F
//