Reviewed, UniProtKB/Swiss-Prot A9MCA1 (UXUA_BRUC2)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	BCAN_B0829

Organism

Brucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP]

Taxonomic identifier

483179 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Mannonate dehydratase HAMAP MF_00106		PRO_1000075896

Sequences

	Sequence		Length	Mass (Da)
	A9MCA1-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 399192F5F46A0921	FASTA	401	44,445
	10 20 30 40 50 60 MRQAWRWFGP EAGVPLDAVR QAGATDIVSA LHEVPIGQEW TSAQIVERKN LIESTPTGRH 70 80 90 100 110 120 PLTWSVVESI PVSDDIKRSG KAARHDIGAW IASMEALARN DIKVICYNFM PVVDWCRTDL 130 140 150 160 170 180 DYITSTGATA MRFDQDRFAA FDLHILQRKG AEKDYSEEDR IAARAIFEAM DETEIEQLIV 190 200 210 220 230 240 NIASALPGST TEPLTIPAFR EKLETYASID AAHLRRNLVE FLEAVTPVAD SLGVKLTLHP 250 260 270 280 290 300 DDPPRSLFGL PRIASTEADY AAIFAAVPAQ SNGMCFCTGS LGVRADNDLP AIARRFASRI 310 320 330 340 350 360 HFSHLRATTR EGDGRTFHEA AHLEGDVDMV GILRILLEED RKRDAGQTII FRSDHGHRMM 370 380 390 400 DDLEKKVTPG YPVIGRMRGL AELRGIITAL DACALEYDPN V

References

[1]

"Brucella canis ATCC 23365 whole genome shotgun sequencing project." Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000873 Genomic DNA. Translation: ABX63988.1.
RefSeq	YP_001594759.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5787288.
GenomeReviews	Gene locus BCAN_B0829 in contig CP000873_GR.
KEGG	bcs:BCAN_B0829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VHEEIKT.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BRUC2

Accession

Primary (citable) accession number: A9MCA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)