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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotation
Ordered Locus Names:BCAN_A2127
OrganismiBrucella canis (strain ATCC 23365 / NCTC 10854)
Taxonomic identifieri483179 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000001385 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000752391 – 202Imidazoleglycerol-phosphate dehydrataseAdd BLAST202

Structurei

3D structure databases

ProteinModelPortaliA9M9R5.
SMRiA9M9R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228064.
KOiK01693.
OMAiARHGLFD.

Family and domain databases

CDDicd07914. IGPD. 1 hit.
HAMAPiMF_00076. HisB. 1 hit.
InterProiView protein in InterPro
IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
PANTHERiPTHR23133. PTHR23133. 1 hit.
PfamiView protein in Pfam
PF00475. IGPD. 1 hit.
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiView protein in PROSITE
PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A9M9R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAESTRKAS IERSTKETSI AVSVDLDGVG KFDITTGVGF FDHMLEQLSR
60 70 80 90 100
HSLIDMRVMA KGDLHIDDHH TVEDTGIALG QAVAKALGER RGIVRYASLD
110 120 130 140 150
LAMDDTLTGA AVDVSGRAFL VWNVNFTTAK IGTFDTELVR EFFQAFAMNA
160 170 180 190 200
GITLHINNHY GANNHHIAES TFKAVARVLR AALETDPRQK DAIPSTKGSL

KG
Length:202
Mass (Da):21,957
Last modified:February 5, 2008 - v1
Checksum:i3EADDC8DEA1A901C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000872 Genomic DNA. Translation: ABX63110.1.
RefSeqiWP_002967034.1. NC_010103.1.

Genome annotation databases

EnsemblBacteriaiABX63110; ABX63110; BCAN_A2127.
GeneIDi29594925.
KEGGibcs:BCAN_A2127.

Similar proteinsi

Entry informationi

Entry nameiHIS7_BRUC2
AccessioniPrimary (citable) accession number: A9M9R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: June 7, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families