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A9M9H8

- BETA_BRUC2

UniProt

A9M9H8 - BETA_BRUC2

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei465 – 4651UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3330FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciBCAN483179:GJ7I-558-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:BCAN_A0565
    OrganismiBrucella canis (strain ATCC 23365 / NCTC 10854)
    Taxonomic identifieri483179 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000001385: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000083492Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi483179.BCAN_A0565.

    Structurei

    3D structure databases

    ProteinModelPortaliA9M9H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiLTDDYNG.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9M9H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS    50
    FPMNMETYDW GFSSEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAC 100
    DFDHWSQSGA RGWAYADVLP YFKRMENSQG GQEGWRGTNG PLYVQRGKRD 150
    NPLFHAFVEA GHQAGFEVAD DYNGEKQEGF GPMEQTIHNG RRWSAANAYL 200
    KPALKRPNVK LVKGFARKIV LEGKRAVGVE IEAGRTFSTI RARREVIIAA 250
    SSINSPKLLM LSGIGPAAHL KEHGIDLVAD RPGVGQNLQD HLEVYIQQEC 300
    TQPITLYSEL NLFSKARIGV EWLLFKTGDG ATNHFESAAF VRSKAGVEYP 350
    DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP 400
    VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFDPYRGAEI QPGAHVQTDD 450
    EIDNFIREHV ESAFHPCGTC KMGAVDDPMA VVDPECRVIG VEGLRVADSS 500
    IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSNQEPWI NPRWQVSDR 549
    Length:549
    Mass (Da):60,594
    Last modified:February 5, 2008 - v1
    Checksum:iBE54097F5EFBEA02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000872 Genomic DNA. Translation: ABX61642.1.
    RefSeqiYP_001592413.1. NC_010103.1.

    Genome annotation databases

    EnsemblBacteriaiABX61642; ABX61642; BCAN_A0565.
    GeneIDi5785572.
    KEGGibcs:BCAN_A0565.
    PATRICi17829797. VBIBruCan25663_0572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000872 Genomic DNA. Translation: ABX61642.1 .
    RefSeqi YP_001592413.1. NC_010103.1.

    3D structure databases

    ProteinModelPortali A9M9H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 483179.BCAN_A0565.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX61642 ; ABX61642 ; BCAN_A0565 .
    GeneIDi 5785572.
    KEGGi bcs:BCAN_A0565.
    PATRICi 17829797. VBIBruCan25663_0572.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi LTDDYNG.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci BCAN483179:GJ7I-558-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23365 / NCTC 10854.

    Entry informationi

    Entry nameiBETA_BRUC2
    AccessioniPrimary (citable) accession number: A9M9H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3