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A9M8Z9 (KHSE_BRUC2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:BCAN_A0483
OrganismBrucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP]
Taxonomic identifier483179 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301

Sequence similarities

Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Homoserine kinase HAMAP MF_00301
PRO_1000079016

Sequences

Sequence LengthMass (Da)Tools
A9M8Z9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 1543E87591431AE6

FASTA32636,629
        10         20         30         40         50         60 
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 

        70         80         90        100        110        120 
DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 

       130        140        150        160        170        180 
VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVERGLVAET EADLDFLEKN 

       190        200        210        220        230        240 
WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 

       250        260        270        280        290        300 
RTKGAALLRG YTSVRPLSEA EADALPVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 

       310        320 
YVRRMRFHRQ IESAAEYGLE MQGVAA

« Hide

References

[1]"Brucella canis ATCC 23365 whole genome shotgun sequencing project."
Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. expand/collapse author list , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23365 / NCTC 10854.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000872 Genomic DNA. Translation: ABX61563.1.
RefSeqYP_001592334.1. NC_010103.1.

3D structure databases

ProteinModelPortalA9M8Z9.
SMRA9M8Z9. Positions 5-319.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9M8Z9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5785379.
GenomeReviewsGene locus BCAN_A0483 in contig CP000872_GR.
KEGGbcs:BCAN_A0483.
PATRIC17829642. VBIBruCan25663_0494.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG309377.
OMAICLNAWC.
ProtClustDBPRK05231.

Enzyme and pathway databases

BioCycBCAN483179:BCAN_A0483-MONOMER.

Family and domain databases

HAMAPMF_00301. Homoser_kinase_2.
[Tree]
InterProIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
KOK02204.
PfamPF01636. APH. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
TIGRFAMsTIGR00938. ThrB_alt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKHSE_BRUC2
AccessionPrimary (citable) accession number: A9M8Z9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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