Reviewed, UniProtKB/Swiss-Prot A9M8W7 (PSD_BRUC2)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BCAN_A0447

Organism

Brucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP]

Taxonomic identifier

483179 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Phosphatidylserine decarboxylase beta chain By similarity		PRO_1000082916
	Chain	190 – 232	43	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_1000082917
Sites
	Site	189 – 190	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	190	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9M8W7-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 34915E274891E149	FASTA	232	25,794
	10 20 30 40 50 60 MSLTDTIRNT FVPIHREGYP FIAGFFVVSL ILGWLWDPLF WIGMVLTVWC IYFYRDPERV 70 80 90 100 110 120 TPMDDDLVIS PADGKVSFVG LAVPPAELDL GYEPMTRVSV FMNVFSVHIN RSPVRGKIDK 130 140 150 160 170 180 VVHRPGKFLN AELDKASTEN ERNSVLIESP HGKVGVVQIA GLVARRIVCW SNQDDELSVG 190 200 210 220 230 ERFGLIRFGS RVDVYLPSDA TVRVAVGQTA IAGETVLADY GTERGEPVVR IA

References

[1]

"Brucella canis ATCC 23365 whole genome shotgun sequencing project." Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000872 Genomic DNA. Translation: ABX61531.1.
RefSeq	YP_001592302.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5785667.
GenomeReviews	Gene locus BCAN_A0447 in contig CP000872_GR.
KEGG	bcs:BCAN_A0447.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A9M8W7. DKASEDN.
Family and domain databases
HAMAP	MF_00664. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BRUC2

Accession

Primary (citable) accession number: A9M8W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	June 16, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)