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A9M757 (PNCB_BRUC2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:BCAN_A0115
OrganismBrucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP]
Taxonomic identifier483179 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000082323

Sequences

Sequence LengthMass (Da)Tools
A9M757 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: AC991EC0BED28239

FASTA43449,918
        10         20         30         40         50         60 
MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS LINRTSSVRL 

        70         80         90        100        110        120 
ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI FQPEFLAWLH DFHLPEYELR 

       130        140        150        160        170        180 
RKDGQYELHF HGPWTHTTMW EIPALAIINE LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV 

       190        200        210        220        230        240 
ERLRQLPDLK ISDFGTRRRH SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN 

       250        260        270        280        290        300 
AHELPMVLAA LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 

       310        320        330        340        350        360 
WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR HFEGRVRMGF 

       370        380        390        400        410        420 
GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK LSDNPQKATG DPKEVARYLR 

       430 
FFGNEERVEQ LVRV 

« Hide

References

[1]"Brucella canis ATCC 23365 whole genome shotgun sequencing project."
Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. expand/collapse author list , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23365 / NCTC 10854.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000872 Genomic DNA. Translation: ABX61216.1.
RefSeqYP_001591987.1. NC_010103.1.

3D structure databases

ProteinModelPortalA9M757.
SMRA9M757. Positions 1-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING483179.BCAN_A0115.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX61216; ABX61216; BCAN_A0115.
GeneID5784401.
KEGGbcs:BCAN_A0115.
PATRIC17828878. VBIBruCan25663_0117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284929.
KOK00763.
OMASIVCKVI.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

BioCycBCAN483179:GJ7I-114-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_BRUC2
AccessionPrimary (citable) accession number: A9M757
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways