ID   A9M6U8_BRUC2            Unreviewed;       261 AA.
AC   A9M6U8;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Heme exporter protein C {ECO:0000256|ARBA:ARBA00016463, ECO:0000256|RuleBase:RU364092};
DE   AltName: Full=Cytochrome c-type biogenesis protein {ECO:0000256|RuleBase:RU364092};
GN   Name=ccmC {ECO:0000256|RuleBase:RU364092,
GN   ECO:0000313|EMBL:ABX61199.1};
GN   OrderedLocusNames=BCAN_A0098 {ECO:0000313|EMBL:ABX61199.1};
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=483179 {ECO:0000313|EMBL:ABX61199.1, ECO:0000313|Proteomes:UP000001385};
RN   [1] {ECO:0000313|EMBL:ABX61199.1, ECO:0000313|Proteomes:UP000001385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23365 / NCTC 10854 {ECO:0000313|Proteomes:UP000001385};
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes. {ECO:0000256|ARBA:ARBA00002442,
CC       ECO:0000256|RuleBase:RU364092}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU364092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family.
CC       {ECO:0000256|ARBA:ARBA00005840, ECO:0000256|RuleBase:RU364092}.
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DR   EMBL; CP000872; ABX61199.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9M6U8; -.
DR   KEGG; bcs:BCAN_A0098; -.
DR   HOGENOM; CLU_066538_2_1_5; -.
DR   Proteomes; UP000001385; Chromosome I.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR   InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR   NCBIfam; TIGR01191; ccmC; 1.
DR   PANTHER; PTHR30071:SF17; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1.
DR   PANTHER; PTHR30071; HEME EXPORTER PROTEIN C; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   PRINTS; PR01386; CCMCBIOGNSIS.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364092};
KW   Cell membrane {ECO:0000256|RuleBase:RU364092};
KW   Cytochrome c-type biogenesis {ECO:0000256|RuleBase:RU364092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364092};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU364092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU364092}; Transport {ECO:0000256|RuleBase:RU364092}.
FT   TRANSMEM        26..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364092"
FT   TRANSMEM        67..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364092"
FT   TRANSMEM        100..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364092"
FT   TRANSMEM        131..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364092"
FT   TRANSMEM        162..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364092"
FT   TRANSMEM        205..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364092"
FT   DOMAIN          11..188
FT                   /note="Cytochrome c assembly protein"
FT                   /evidence="ECO:0000259|Pfam:PF01578"
SQ   SEQUENCE   261 AA;  29087 MW;  F5D2E3B7AC9B8724 CRC64;
     MKDAAKTASW LDLANPTRFL AFAGRVVPWL GLASAIFLAV GLYMVFLSPD DYQQGSTVRI
     MYIHVPFAWL SMMCYSIMAV SSLGTLVWRH PLADVSVRAA APIGAVFTAL ALATGSLWGK
     PMWGTWWVWD ARLTSVFVLF LMYLGIIALS RAMDDPARSA KPVAVLTLVG FINVPIIKFS
     VDWWNTLHQP ASVFRLDGPT IDGSMLRPLF VMAIGFTLLF FTLHMMAMRN EIWRRRVASM
     KKLAARNVDR NRAGQVEEGA L
//