Reviewed,
UniProtKB/Swiss-Prot A9M6L4 (HEM6_BRUC2)
Last modified
January 19, 2010.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Coproporphyrinogen-III oxidase, aerobic Short name=Coproporphyrinogenase Short name=Coprogen oxidase EC=1.3.3.3 | ||||
| Gene names |
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| Organism | Brucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 483179 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 |
| Catalytic activity | Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00333 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00333. |
| Sequence similarities | Belongs to the aerobic coproporphyrinogen-III oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP protein homodimerization activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333 | PRO_1000119789 | |||||
Regions | |||||||||
| Region | 72 – 81 | 10 | Important for dimerization By similarity | ||||||
| Region | 132 – 134 | 3 | Substrate binding By similarity | ||||||
| Region | 268 – 303 | 36 | Important for dimerization By similarity | ||||||
| Region | 286 – 291 | 6 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 130 | 1 | Proton donor By similarity | ||||||
| Binding site | 116 | 1 | Substrate By similarity | ||||||
| Site | 199 | 1 | Important for dimerization By similarity | ||||||
Sequences
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References
| [1] | "Brucella canis ATCC 23365 whole genome shotgun sequencing project." Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. Brettin T.S.Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000872 Genomic DNA. Translation: ABX62610.1. |
| RefSeq | YP_001593381.1. |
3D structure databases | |
| SMR | A9M6L4. Positions 20-303. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5785224. |
| GenomeReviews | Gene locus BCAN_A1586 in contig CP000872_GR. |
| KEGG | bcs:BCAN_A1586. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG631180. |
| OMA | HMNTRFV. |
Family and domain databases | |
| HAMAP | MF_00333. Coprogen_oxidas. [Tree] |
| InterPro | IPR001260. Coprogen_oxidas. IPR018375. Coproporphyrinogen-3_ox_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit. |
| PANTHER | PTHR10755. Coprogen_oxidas. 1 hit. |
| Pfam | PF01218. Coprogen_oxidas. 1 hit. [Graphical view] |
| PIRSF | PIRSF000166. Coproporphyri_ox. 1 hit. |
| PRINTS | PR00073. COPRGNOXDASE. |
| PROSITE | PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HEM6_BRUC2 | ||||||||
| Accession | Primary (citable) accession number: A9M6L4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


