Skip Header

Contribute Send feedback
Read comments (?) or add your own

A9M693 (MRAY_BRUC2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BCAN_A1467
OrganismBrucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP]
Taxonomic identifier483179 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000074534

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane337 – 35721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9M693 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 72C41260FD120E78

FASTA36038,745
        10         20         30         40         50         60 
MLMFLTHFAE HVTPFNVFRY ITFRTGGAMI TSALIVFLFG PTIINSLRVR QGKGQPIRAD 

        70         80         90        100        110        120 
GPQTHFKKAG TPTMGGLMIM TGILASCLLW ANLASVYVWV VLMVSVGFGA IGFYDDYLKV 

       130        140        150        160        170        180 
TKQSDKGFSG KARLGIEFLI AAIAAFTIMR AGQEPFSSSL TFPFVKQLVI NLSWFFIPFA 

       190        200        210        220        230        240 
AFVMVGAGNA VNLTDGLDGL AIVPVMVAAA SFGFIAYLSG NAIFADYLQI HFVPGTGELA 

       250        260        270        280        290        300 
VVLGAVIGAG LGFLWFNAPP AAIFMGDTGS LALGGMLGTV AVATKHEIVL AIIGGLFVME 

       310        320        330        340        350        360 
ALSVIIQVGF FKMTGRRVFL MAPIHHHFEK KGWTESQVVI RFWIVAIILA MIGLSTLKLR

« Hide

References

[1]"Brucella canis ATCC 23365 whole genome shotgun sequencing project."
Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. expand/collapse author list , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23365 / NCTC 10854.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000872 Genomic DNA. Translation: ABX62498.1.
RefSeqYP_001593269.1. NC_010103.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA9M693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5786036.
GenomeReviewsGene locus BCAN_A1467 in contig CP000872_GR.
KEGGbcs:BCAN_A1467.
PATRIC17831633. VBIBruCan25663_1468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBCAN483179:BCAN_A1467-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BRUC2
AccessionPrimary (citable) accession number: A9M693
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents