Skip Header

Contribute Send feedback
Read comments (?) or add your own

A9M690 (MURG_BRUC2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BCAN_A1464
OrganismBrucella canis (strain ATCC 23365 / NCTC 10854) [Complete proteome] [HAMAP]
Taxonomic identifier483179 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_1000074448

Sequences

Sequence LengthMass (Da)Tools
A9M690 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: EA3EE99D4C9F3B80

FASTA37940,208
        10         20         30         40         50         60 
MDNLANQGVI VLAAGGTGGH LFPAEALAHE LRARGWDVHL ATDARAQRFV GAFAQDHVHV 

        70         80         90        100        110        120 
IRSATIAGRN PVALLKTFWS LWQGNLDSRK LFRRLKPKLV VGFGGYPTLP PLYAASNMGI 

       130        140        150        160        170        180 
PTLIHEQNAV MGRANKGLAG RVKAIAGGFL PENSGAYAAK TVITGNPVRP PVLVAAATPY 

       190        200        210        220        230        240 
TPAGKDDRFR LLVFGGSQGA QFFSQAIPAA VALLPEHERA RLLITQQARK EDEASARKAY 

       250        260        270        280        290        300 
EKLGVPADVA PFFNDMPARM ADAHFVIARS GASTVSEITV IGRPAMLVPF PHALDHDQAA 

       310        320        330        340        350        360 
NAAALAAAGG AEVVRQADLS PQRLAEMLQS AMNEPERLEQ QAKAAKSVGK PDAARLLADL 

       370 
AEAIASGKTV QEFKEGNRP

« Hide

References

[1]"Brucella canis ATCC 23365 whole genome shotgun sequencing project."
Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. expand/collapse author list , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23365 / NCTC 10854.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000872 Genomic DNA. Translation: ABX62495.1.
RefSeqYP_001593266.1. NC_010103.1.

3D structure databases

ProteinModelPortalA9M690.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9M690.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5784722.
GenomeReviewsGene locus BCAN_A1464 in contig CP000872_GR.
KEGGbcs:BCAN_A1464.
PATRIC17831627. VBIBruCan25663_1465.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBCAN483179:BCAN_A1464-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BRUC2
AccessionPrimary (citable) accession number: A9M690
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents