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A9M586

- GCH1_BRUC2

UniProt

A9M586 - GCH1_BRUC2

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Protein

GTP cyclohydrolase 1

Gene
folE, BCAN_A1090
Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi104 – 1041Zinc By similarity
Metal bindingi107 – 1071Zinc By similarity
Metal bindingi175 – 1751Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBCAN483179:GJ7I-1078-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:BCAN_A1090
OrganismiBrucella canis (strain ATCC 23365 / NCTC 10854)
Taxonomic identifieri483179 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001385: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213GTP cyclohydrolase 1UniRule annotationPRO_1000078135Add
BLAST

Interactioni

Subunit structurei

Homopolymer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi483179.BCAN_A1090.

Structurei

3D structure databases

ProteinModelPortaliA9M586.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiGENPARE.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9M586-1 [UniParc]FASTAAdd to Basket

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MDARILQDND DTSLPVNQAS VTRIHKKPGK AEAEAAVRTL LLWAGEDPDR    50
EGLLETPKRV AKAYQELFGG YSESPEEVLG TTFEEVAGYD DMVLVKDISF 100
FSHCEHHMVP IIGKAHVAYL PEGRVVGLSK IARVVDIFAR RLQTQESITA 150
QIADSMQRIL KPRGVAVMIE AEHMCMAMRS IRKQGSSTIT TTFTGDFKEK 200
ADQQVRFMTL IRT 213
Length:213
Mass (Da):23,794
Last modified:February 5, 2008 - v1
Checksum:iB43866DF2C208BB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000872 Genomic DNA. Translation: ABX62141.1.
RefSeqiYP_001592912.1. NC_010103.1.

Genome annotation databases

EnsemblBacteriaiABX62141; ABX62141; BCAN_A1090.
GeneIDi5784077.
KEGGibcs:BCAN_A1090.
PATRICi17830875. VBIBruCan25663_1098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000872 Genomic DNA. Translation: ABX62141.1 .
RefSeqi YP_001592912.1. NC_010103.1.

3D structure databases

ProteinModelPortali A9M586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 483179.BCAN_A1090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX62141 ; ABX62141 ; BCAN_A1090 .
GeneIDi 5784077.
KEGGi bcs:BCAN_A1090.
PATRICi 17830875. VBIBruCan25663_1098.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi GENPARE.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BCAN483179:GJ7I-1078-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23365 / NCTC 10854.

Entry informationi

Entry nameiGCH1_BRUC2
AccessioniPrimary (citable) accession number: A9M586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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