Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A9M3N5

- GCH4_NEIM0

UniProt

A9M3N5 - GCH4_NEIM0

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei188 – 1881May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciNMEN374833:GJ7Z-765-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:NMCC_0766
    OrganismiNeisseria meningitidis serogroup C (strain 053442)
    Taxonomic identifieri374833 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000001177: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298GTP cyclohydrolase FolE2PRO_0000372031Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374833.NMCC_0766.

    Structurei

    3D structure databases

    ProteinModelPortaliA9M3N5.
    SMRiA9M3N5. Positions 56-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9M3N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLLKASDII SHLQIDGIFP GGNAIPCTHL NNYMNIKEKQ LMNTIADVQS    50
    SRDLRNLPIN QVGIKDLRFP ITLQTAEGIQ STIARLTMTV YLPAEQKGTH 100
    MSRFVALMEQ YSEALDFAQL HRLTAEMVAL LDSRAGKISV SFPFFRKKTA 150
    PVSGIQSLLD YDVCLTGEMK DGAYGHSMKV MIPVTSLCPC SKEISQYGAH 200
    NQRSHVTVSL TADAEVGIEE VIDYVEAQAS CQLYGLLKRP DEKYVTEKAY 250
    ENPKFVEDMV RDVATSLIAD KRIKSFVVES ENFESIHNHS AYAYIAYP 298
    Length:298
    Mass (Da):33,291
    Last modified:February 5, 2008 - v1
    Checksum:iC7CEB9D337271894
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000381 Genomic DNA. Translation: ABX72959.1.
    RefSeqiYP_001598914.1. NC_010120.1.

    Genome annotation databases

    EnsemblBacteriaiABX72959; ABX72959; NMCC_0766.
    GeneIDi5795111.
    KEGGinmn:NMCC_0766.
    PATRICi20345995. VBINeiMen117761_0920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000381 Genomic DNA. Translation: ABX72959.1 .
    RefSeqi YP_001598914.1. NC_010120.1.

    3D structure databases

    ProteinModelPortali A9M3N5.
    SMRi A9M3N5. Positions 56-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374833.NMCC_0766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX72959 ; ABX72959 ; NMCC_0766 .
    GeneIDi 5795111.
    KEGGi nmn:NMCC_0766.
    PATRICi 20345995. VBINeiMen117761_0920.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci NMEN374833:GJ7Z-765-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
      Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
      Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 053442.

    Entry informationi

    Entry nameiGCH4_NEIM0
    AccessioniPrimary (citable) accession number: A9M3N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3