A9M3K6 (UPP_NEIM0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uracil phosphoribosyltransferase
EC=2.4.2.9

Alternative name(s):
UMP pyrophosphorylase
UPRTase

Gene names

Name:	upp
Ordered Locus Names:	NMCC_0738

Organism

Neisseria meningitidis serogroup C (strain 053442) [Complete proteome] [HAMAP]

Taxonomic identifier

374833 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis › Neisseria meningitidis serogroup C

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218
Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218
Cofactor	Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.
Enzyme regulation	Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218
Pathway	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218
Sequence similarities	Belongs to the UPRTase family.

Ontologies

Keywords
Ligand	GTP-binding Magnesium Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological_process	UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway uracil salvage Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Uracil phosphoribosyltransferase HAMAP-Rule MF_01218		PRO_1000085630
Regions
	Region	130 – 138	9	5-phospho-alpha-D-ribose 1-diphosphate binding By similarity
	Region	198 – 200	3	Uracil binding By similarity
Sites
	Binding site	78	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity
	Binding site	103	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity
	Binding site	193	1	Uracil; via amide nitrogen By similarity
	Binding site	199	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9M3K6 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 7C1E6F6601200D04	FASTA	208	22,740
	10 20 30 40 50 60 MNVNVINHPL VRHKLTLMRE ADCSTYKFRT LAIELARLMA YEASRDFEIE KYLIDGWCGQ 70 80 90 100 110 120 IEGDRIKGKT LTVVPILRAG LGMLDGVLDL IPTAKISVVG LQRDEETLKP VSYFEKFVDS 130 140 150 160 170 180 MDERPALIID PMLATGGSMV ATIDLLKAKG CKNIKALVLV AAPEGVKAVN DAHPDVTIYT 190 200 AALDSHLNEN GYIIPGLGDA GDKIFGTR

References

[1]

"Characterization of ST-4821 complex, a unique Neisseria meningitidis clone." Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q. Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 053442.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000381 Genomic DNA. Translation: ABX72931.1.
RefSeq	YP_001598885.1. NC_010120.1.
3D structure databases
ProteinModelPortal	A9M3K6.
SMR	A9M3K6. Positions 6-208.
ModBase	Search...
Protein-protein interaction databases
STRING	374833.NMCC_0738.
Proteomic databases
PRIDE	A9M3K6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX72931; ABX72931; NMCC_0738.
GeneID	5796403.
KEGG	nmn:NMCC_0738.
PATRIC	20345921. VBINeiMen117761_0883.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0035.
HOGENOM	HOG000262754.
KO	K00761.
OMA	TIEGWCG.
ProtClustDB	PRK00129.
Enzyme and pathway databases
BioCyc	NMEN374833:GJ7Z-736-MONOMER.
UniPathway	UPA00574; UER00636.
Family and domain databases
HAMAP	MF_01218_B. Upp_B.
InterPro	IPR000836. PRibTrfase_dom. IPR005765. Ura_phspho_trans. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01091. upp. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPP_NEIM0

Accession

Primary (citable) accession number: A9M3K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program